母亲早期怀孕的体重指数和双相情感障碍在后代
Rachael J Beer1, Sven Cnattingius2, Ezra S Susser3
1Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
Bipolar disorders
|November 21, 2023
概括
怀孕早期母亲体重指数 (BMI) 升高与后代患双相情感障碍 (BPD) 的风险增加有关. 这种关联似乎取决于剂量,较高的BMI与更高的风险相关.
科学领域:
- 生殖健康 生殖健康
- 精神病学是一个精神病学.
- 流行病学 流行病学
背景情况:
- 孕前母亲的体重指数 (BMI) 是妊娠结果的一个重要因素.
- 了解母亲的BMI对后代心理健康的长期影响至关重要.
研究的目的:
- 检查母亲早期怀孕BMI与后代双相情感障碍 (BPD) 风险之间的关系.
- 通过大规模的全国性队列研究来量化这种关联.
主要方法:
- 全国范围内对1,507,056名瑞典活产婴儿 (1983-2004) 的队列研究.
- 从13岁到35岁使用国家登记册对BPD诊断的随访.
- 使用了调整后的考克斯模型和兄弟控制分析.
主要成果:
- 观察到母亲早期怀孕BMI与后代BPD风险之间存在积极的关联.
- 超重和肥胖的母亲 (BMI ≥25) 与正常的BMI相比,子女患BPD的风险明显更高.
- 风险以较高的母亲BMI类别以剂量反应的方式增加.
结论:
- 在怀孕早期,母亲的BMI为25或以上与后代患双相情感障碍的风险增加有关.
- 这种关联表明了剂量与反应的关系,突出显示了母亲体重的影响.
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