关于怀孕期间不良暴露对后代骨肌功能影响的研究进展
Rui Liu1,2, Jianzhong Sheng3,4, Hefeng Huang5,6,7,8
1Center for Reproductive Medicine, the Fourth Affiliated Hospital of School of Medicine, International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu 322000, Zhejiang Province, China. 12018526@zju.edu.cn.
概括
孕妇在怀孕期间的暴露,包括肥胖和饮食不良,可能会对胎儿骨肌的发育和功能产生负面影响. 了解这些影响是预防出生缺陷和改善后代骨肌肉健康的关键.
科学领域:
- 发育生物学是发展生物学.
- 孕产妇和胎儿的医学
- 骨肌肉生理学 骨肌肉生理学
背景情况:
- 骨肌肉对新陈代谢,能量,运动和内分泌功能至关重要.
- 孕期是胎儿骨肌肉发育 (肌体发生) 的关键时期.
- 怀孕期间母亲的不良暴露会影响后代的骨肌肉健康.
研究的目的:
- 审查关于怀孕期间母亲的不良暴露及其对后代骨肌肉功能的影响的研究.
- 探索这些影响的潜在机制.
- 为预防和治疗骨肌肉出生缺陷提供证据.
主要方法:
- 临床和动物研究的审查.
- 分析母亲暴露的情况,如肥胖,饮食不良,营养不足,妊娠期糖尿病和内分泌干扰物.
- 检查对胎儿骨肌肉代谢,炎症,自,表观遗传学和信号通路的影响.
主要成果:
- 孕产妇的肥胖会导致后代骨肌肉中的脂质沉积.
- 糟糕的孕产妇饮食会影响线粒体自和骨肌肉质量.
- 营养不足会导致表观遗传变化,影响骨肌肉发育.
- 孕期糖尿病可能会改变miR-15a/15b水平,影响骨肌肉功能.
- 内分泌干扰剂可以通过胰岛素信号通路损害骨肌肉功能.
结论:
- 怀孕期间母亲的不良暴露显著影响后代的骨肌肉发育和功能.
- 机制包括代谢,炎症,表观遗传和信号通路的改变.
- 证据支持需要策略来减轻不利的母亲暴露,以改善后代的骨肌肉健康.
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