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在体育以外的样本中检测包括选择性雄激素受体调节器在内的合成代谢剂

Kim Petterson Bohlin^1,2, Anton Pohanka^1,2, Alexander Andersson^1,2

¹Department of Laboratory Medicine, Karolinska Institute, Stockholm, Sweden.

Drug testing and analysis

|November 21, 2023

概括

选择性雄激素受体调节剂 (SARMs) 在体育兴奋剂控制之外的男性尿样中越来越多地被检测到. 这表明潜在的公共卫生问题,需要在医疗保健系统内提高认识和查.

科学领域:

药理学药理学是指药理学的学科.
毒理学毒理学毒理学
分析化学分析化学

背景情况:

选择性雄激素受体调节剂 (SARMs) 由世界反兴奋剂机构 (WADA) 禁止使用,原因是健康风险,类似于类固醇类固醇 (AAS).
关于SARM在精英体育以外的普通人群中使用率的数据有限.
了解SARM的发生对于公共卫生监测和临床意识至关重要.

研究的目的:

估计瑞典医疗保健机构中SARM使用的频率.
为了识别常见的SARM和同伴存在的物质,如AAS.
评估SARM和AAS检测中的潜在性别差异.

主要方法:

分析了542个男性和100个女性的尿样,使用了WADA认可的查方法.
气色谱-质谱 (GC-MS) 和液色谱-质谱 (LC-MS) 用于SARM和AAS检测.
对潜在的滥用的 / 酸比率的评估.

主要成果:

20个 (4%) 的男性尿液样本对SARM呈阳性,而女性样本没有.
LGD-4033,RAD140和奥斯塔林是最经常检测到的SARM.
超过50%的SARM阳性样本含有多个SARM,40%也含有AAS.

结论:

SARM的使用代表了越来越多的担忧超出了职业体育的领域.
医疗保健提供者应被告知SARM滥用及其不良健康影响.
目前的查方法可能需要改进,以检测所有形式的增强性能的药物滥用,包括摄入量.

关键词:

这就是AAS AAS AAS.一个SARM就是SARM.兴奋剂的使用兴奋剂的使用测试剂测试剂测试剂测试剂

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