相关实验视频

Updated: Jul 10, 2025

Measurement of Natural Killer Cell-Mediated Cytotoxicity and Migration in the Context of Hepatic Tumor Cells
06:55

Measurement of Natural Killer Cell-Mediated Cytotoxicity and Migration in the Context of Hepatic Tumor Cells

Published on: February 22, 2020

18.7K

自然杀手细胞中的早期抗原受体信号改变了通过表观遗传改造的STAT4依赖性命运决定

Simon Grassmann, Endi K Santosa, Adriana M Mujal

    bioRxiv : the preprint server for biology
    |November 21, 2023
    PubMed
    概括

    抗原受体信号传递在表观遗传上启动自然杀手 (NK) 细胞,以便在病毒感染期间实现最佳扩张. 这种早期信号影响NK细胞命运决定,增强了自适应性抗病毒反应.

    更多相关视频

    A Novel Feeder-free System for Mass Production of Murine Natural Killer Cells In Vitro10:36

    A Novel Feeder-free System for Mass Production of Murine Natural Killer Cells In Vitro

    Published on: January 9, 2018

    7.2K
    Assessment of Human Natural Killer Cell Events Driven by FcγRIIIa Engagement in the Presence of Therapeutic Antibodies09:54

    Assessment of Human Natural Killer Cell Events Driven by FcγRIIIa Engagement in the Presence of Therapeutic Antibodies

    Published on: May 22, 2020

    3.6K

    相关概念视频

    The JAK-STAT Signaling Pathway01:20

    The JAK-STAT Signaling Pathway

    Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
    8.9K
    Cells of the Innate Immune Response01:28

    Cells of the Innate Immune Response

    The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
    Phagocytes
    Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
    1.7K
    NF-κB-dependent Signaling Pathway02:26

    NF-κB-dependent Signaling Pathway

    The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
    NF-κB-dependent Signaling Mechanism
    The...
    7.5K
    Immune Surveillance by NK Cells and Phagocytes01:25

    Immune Surveillance by NK Cells and Phagocytes

    Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
    Natural Killer Cells: The Fast Responders
    NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
    1.4K
    Diversity of Antigen Receptors01:28

    Diversity of Antigen Receptors

    Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
    Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
    595
    Receptor Downregulation in MVBs01:15

    Receptor Downregulation in MVBs

    Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
    The EGFR can initiate signaling pathways that  lead to cell proliferation, migration, and differentiation. Overexpression of EGFR  stimulates cells to proliferate. Excessive  EGFR...
    2.1K