接种后综合症:对COVID-19免疫接种后报告的症状和患者经历的描述性分析
Harlan M Krumholz1,2,3,4, Yilun Wu1,5, Mitsuaki Sawano1,3
1Center for Outcomes Research and Evaluation, Yale New Haven Hospital, New Haven, Connecticut.
medRxiv : the preprint server for health sciences
|November 21, 2023
概括
在COVID-19疫苗接种后,慢性接种后综合征 (PVS) 具有显著的症状负担和心理社会痛苦的特征. 需要进一步的研究来了解和有效治疗这种情况.
科学领域:
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
- 临床医学 临床医学
背景情况:
- 在COVID-19疫苗接种后出现的疫苗接种后综合征 (PVS) 已有事报告,但缺乏全面的描述.
- 了解PVS的临床特征对于患者护理和公共卫生战略至关重要.
研究的目的:
- 描述COVID-19疫苗接种后报告PVS的个人的人口统计,健康状况,症状和治疗经验.
- 提供对这种患者群体生活经验和未满足需求的见解.
主要方法:
- 一项涉及241名在COVID-19疫苗接种后自我报告PVS的成年人的横截面研究.
- 通过在线的耶鲁听免疫,症状和治疗经验现在 (LISTEN) 研究在2022年5月至2023年7月期间收集的数据.
- 分析包括人口统计,健康状况 (Euro-QoL VAS),症状流行率和报告的干预措施.
主要成果:
- 参与者的平均年龄为46岁,80%的人认为自己是女性,87%的人认为自己是非西班牙裔白人.
- 常见的症状包括运动不耐受 (71%),疲劳 (69%),麻木 (63%),脑雾 (63%) 和神经病 (63%).
- 参与者经历了显著的心理痛苦,包括不安 (93%),恐惧 (82%),焦虑 (76%),抑郁 (76%),并尝试了20项干预的中位数.
结论:
- 接种COVID-19疫苗后患有PVS的个人表现出大量的身体症状和心理痛苦.
- 尽管进行了多次治疗尝试,但参与者报告健康状况不佳,这表明需要改进治疗策略.
- 进一步的研究对于阐明病理生理学和开发疫苗接种后综合征的有效治疗方法至关重要.
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