是大肠杆菌引起复发性囊炎只是普通的尿病原体E. 大肠杆菌 (UPEC) 的菌株?
Nicolas Vautrin1, Sandrine Dahyot2, Marie Leoz1
1Univ Rouen Normandie, Université de Caen Normandie, INSERM, Normandie Univ, DYNAMICURE UMR 1311, F-76000 Rouen, France.
bioRxiv : the preprint server for biology
|November 21, 2023
概括
引起复发性囊炎的尿病原菌大肠杆菌 (UPEC) 在宿主体内迅速适应,经常失去等离子体. 这种适应涉及新陈代谢和膜运输基因的变化,而不是特定的毒性因素.
科学领域:
- 微生物学 微生物学
- 基因组学就是基因组学.
- 传染性疾病 传染性疾病
背景情况:
- 复发性囊炎通常是由尿病原性大肠杆菌 (UPEC) 引起的.
- 导致UPEC复发的基因组和表型因素仍然不太清楚.
- 了解UPEC适应对于开发有效的治疗方法至关重要.
研究的目的:
- 为了确定与复发的UPEC囊炎相关的基因组和表型特征.
- 在复发期间调查宿主内UPEC基因组进化.
- 为了比较反复的UPEC分离物 (RCIs) 与零星的UPEC分离物 (SCIs).
主要方法:
- 24个RCI和24个配对的SCI的全基因组比较分析.
- 来自24名患者的顺序UPEC分离物的分析,以追踪患者内演变.
- 现型特征包括健康状况,生物膜形成和宿主细胞入侵试验.
主要成果:
- 与SCIs相比,RCIs显示移动遗传元素 (MGE) 的流行率较低,比如等离子体和菌体.
- 患者内部的UPEC进化涉及代谢和膜运输基因中的单核酸多态 (SNPs).
- 在24个复发的UPEC系列中,在5个中观察到等离子体损失.
- 在特定的毒性因子,健康状况,生物膜形成或入侵能力方面,RCI与SCI没有区别.
- 基因组适应发生在复发的早期,表明迅速适应尿路环境.
结论:
- 在复发性囊炎期间的UPEC适应是快速的和菌株特异的,不一定是趋同的.
- 移动遗传元素,特别是等离子体,在适应复发性感染时可能会丢失.
- 适应涉及与代谢和运输相关的核心基因的遗传变化.
- 主体和菌株特异性因素可能在UPEC复发中发挥重要作用.
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