睡眠障碍是晚年神经退行症的危险因素
Emily Simmonds1, Kristin S Levine2,3, Jun Han4
1UK Dementia Research Institute (UKDRI) at Cardiff University, Cardiff, UK.
medRxiv : the preprint server for health sciences
|November 21, 2023
概括
睡眠呼吸暂停等睡眠障碍显著增加神经退行性疾病 (NDD) 的风险,包括阿尔茨海默氏症和帕金森病,在发病前几年. 这些与睡眠相关的风险可以弥补较低的遗传倾向,突出早期干预的潜力.
科学领域:
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
- 遗传学 是一个遗传学.
背景情况:
- 睡眠障碍与神经退行性疾病 (NDD) 之间的联系是复杂的.
- 需要大规模的数据分析来理解这种关系及其对疾病风险的影响.
- 调查睡眠障碍,遗传因素和NDD之间的相互作用对于预防策略至关重要.
研究的目的:
- 为了确定睡眠障碍和随后的NDD发展之间的关联.
- 为了检查睡眠障碍严重程度对神经退行风险的影响.
- 探索与睡眠相关的风险因素是否可以弥补NDD表现的低遗传风险.
主要方法:
- 利用了来自威尔士和芬兰生物库的100多万个电子健康记录 (EHR).
- 进行数据挖掘,以确定诊断的睡眠障碍与NDD之间的关系.
- 分析了睡眠障碍严重程度和累积诊断对神经退行风险的影响,考虑遗传风险得分.
主要成果:
- 睡眠障碍,包括睡眠呼吸暂停,与阿尔茨海默病,帕金森病,痴呆症和血管痴呆症的风险增加有关 (HRs 1.31-5.11).
- 这种风险在NDD诊断前长达15年是显而易见的.
- 累积睡眠障碍增加了痴呆症和血管痴呆症的风险;睡眠因素在低遗传风险的个体中独立与NDD相关.
结论:
- 睡眠障碍是多种NDD的重要,独立的风险因素,即使在具有低遗传倾向的个体中也是如此.
- 可修改的睡眠因素,如睡眠卫生不良和睡眠呼吸暂停,是减少NDD风险的潜在目标.
- 早期发现和治疗睡眠障碍可能是减轻神经退行风险的可行策略.
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