旅行监测揭示了登革热病毒的动态和在加勒比地区的引入
Emma Taylor-Salmon1,2, Verity Hill2, Lauren M Paul3
1Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut, United States of America.
medRxiv : the preprint server for health sciences
|November 21, 2023
概括
加勒比地区的登革热病毒 (DENV) 爆发正在上升,亚洲发现了新的DENV-3引入. 加强旅行者监测对于了解区域DENV流行病学和公共卫生威胁至关重要.
科学领域:
- 流行病学 流行病学
- 病毒学 病毒学
- 基因组学就是基因组学.
背景情况:
- 登革热病毒 (DENV) 是一个主要的全球公共卫生问题,在加勒比地区病例不断增加和频繁爆发.
- 该地区经历了所有四种DENV血清型的超大流行,增加了严重登革热的风险.
- 在加勒比海岛屿进行不一致的监测阻碍了准确的流行病学理解.
研究的目的:
- 重建2009-2022年在加勒比地区的DENV爆发动态,血清型的流动和传播模式.
- 调查最近DENV引入对区域流行病学的影响.
- 评估旅行监控对了解本地DENV传播的有用性.
主要方法:
- 利用旅行监控数据来追踪DENV引入.
- 采用基因组流行病学来分析DENV爆发动态和血清型循环.
- 2009年至2022年间重建的区域DENV传播模式.
主要成果:
- 确定了DENV-3最近从亚洲进入加勒比地区的两次引入.
- 在古巴发现了一个未被报告的DENV-3疫情,与亚洲引入有关.
- 证明了跨岛屿同步爆发可以由不同的DENV血清型驱动.
结论:
- 对感染旅行者的监测对于检测局部DENV引入和传播至关重要,特别是在监测有限的地区.
- 最近的DENV-3引入对加勒比地区构成重大潜在的公共卫生威胁.
- 了解DENV血清型流动和引入模式对于有效的区域疾病控制至关重要.
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