童年不良生活事件和骨肌肉线粒体功能
medRxiv : the preprint server for health sciences
|November 21, 2023
概括
儿童时期的社会压力,就像身体虐待一样,与成年肌肉细胞的能量生产降低有关. 这表明线粒体功能障碍可能解释了早期生活压力如何影响长期健康.
科学领域:
- 老年学是指老年学的学科.
- 分子生物学分子生物学
- 心理学 心理学 心理学
背景情况:
- 儿童时期的社会压力是已知的健康不良后果的风险因素.
- 线粒体功能障碍是一种拟议的生物学机制,将早期生活压力与以后的健康联系起来.
- 骨肌肉的线粒体能量对于老年人的整体身体健康至关重要.
研究的目的:
- 调查儿童不良事件与老年人骨肌肉线粒体能量之间的关联.
- 检查儿童时期的身体虐待是否会影响最大的腺三酸盐产量 (ATPmax) 和最大的状态3呼吸 (Max OXPHOS).
主要方法:
- 利用了来自肌肉,移动性和衰老研究 (n=879) 的数据.
- 采用线性模型来分析童年不良事件和线粒体功能测量之间的关系.
- 评估了两个关键指标:最大的腺三酸盐产量 (ATPmax) 和最大的状态3呼吸 (Max OXPHOS).
主要成果:
- 45%的参与者报告至少经历过一次不良童年事件.
- 在老年人中,每个额外的不良童年事件都与较低的最大腺三酸盐 (ATPmax) 生产显著相关.
- 儿童不良事件和最大状态3呼吸 (Max OXPHOS) 之间没有发现显著的关联.
结论:
- 儿童期不良事件与生活后骨肌肉线粒体ATP产量减少有关.
- 线粒体功能可以作为一种关键的生物学途径,调解早期社会压力的长期健康影响.
- 这些发现强调了童年逆境对细胞能量代谢和衰老的持久影响.
相关概念视频
01:28Disorders of the Skeletal Muscle
966
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
966
01:37Mitochondria
13.4K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
13.4K
01:45Mitochondrial Membranes
11.1K
A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
11.1K
01:13Formation of Muscle Fibers from Myoblasts
4.9K
De novo myogenesis, or the formation of muscle fibers, begins during the early embryonic stages. The skeletal muscle is formed from somites– blocks of embryonic cell layers. The somites are further divided into dermatomes, myotomes, sclerotomes, and syndetomes. Among these, the myotomes give rise to muscle fibers.
Muscle progenitor cells (MPCs) are formed from the myotomes. MPCs express genes that encode the transcription factors Pax3 and Pax7. Along with Pax 3/7, other transcription...
Muscle progenitor cells (MPCs) are formed from the myotomes. MPCs express genes that encode the transcription factors Pax3 and Pax7. Along with Pax 3/7, other transcription...
4.9K