评估和表征COVID-19相关的认知衰退:来自自然实验的结果
Zennur Sekendiz1, Sean A P Clouston2, Olga Morozova3
1Stony Brook University, Department of Medicine-World Trade Center Health Program.
medRxiv : the preprint server for health sciences
|November 21, 2023
概括
COVID-19感染显著损害认知功能,特别是在严重病例或SARS-CoV-2 (PASC) 后急性后续病例中. 这种影响处理速度和记忆的认知衰退是相当大的,需要监测.
科学领域:
- 神经科学是一个神经科学.
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 认知障碍是SARS-CoV-2 (PASC) 后急性后续的常见和致残症状.
- 在COVID-19研究中,需要严格的方法来评估认知结果.
研究的目的:
- 为了调查COVID-19是否导致认知能力下降.
- 将PASC或严重COVID-19患者的认知衰退与轻度COVID-19患者的认知衰退进行比较.
主要方法:
- 一项纵向队列研究比较了276名COVID-19患者和217名对照人群.
- 在四个神经炎症/血管敏感领域评估认知表现.
- 疫情前的数据 (2015年以来) 允许进行纵向分析.
主要成果:
- COVID-19与认知吞吐量显著下降有关 (P=.001).
- 这种下降相当于超过10年的正常衰老,轻度认知障碍负担增加了59.8%.
- 在患有严重COVID-19的患者和报告PASC的患者中,认知能力下降更明显.
结论:
- COVID-19与认知能力下降密切相关,特别是在严重病例和PASC中.
- 监测PASC患者的处理速度和视觉工作记忆是至关重要的.
- 需要进一步的研究来了解COVID-19相关认知缺陷的长期预后.
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