Search research articles

关于 JoVE

概览领导团队博客 JoVE 帮助中心

作者

出版流程编辑委员会范围与政策同行评审常见问题投稿

图书馆员

用户评价订阅访问资源图书馆顾问委员会常见问题

研究

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments 存档

教育

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual 教师资源中心教师网站

使用条款与条件

Search research articles

相关实验视频

Updated: Jul 10, 2025

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.

Published on: May 6, 2010

使用基因组图表改进Hi-C接触矩阵.

Yihang Shen¹, Lingge Yu¹, Yutong Qiu¹

¹Computational Biology Department, School of Computer Science, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA.

bioRxiv : the preprint server for biology

|November 21, 2023

概括

此摘要是机器生成的。

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序

Same author

Coexistent alterations of BAFF and B-cell phenotypes in complicated CVID course.

The Journal of allergy and clinical immunology·2026

Same author

Data-driven AI system for learning how to run transcript assemblers.

Genome biology·2026

Same author

CodonMoE: DNA language models for codon-dependent mRNA prediction.

Bioinformatics (Oxford, England)·2026

Same author

Archetype analysis of lung adenocarcinoma premalignancy links heterogeneity in premalignant lesions to diverging features of invasive disease.

Molecular cancer research : MCR·2026

Same author

CodonRL: Multi-Objective Codon Sequence Optimization Using Demonstration-Guided Reinforcement Learning.

bioRxiv : the preprint server for biology·2026

Same author

seq2ribo: Structure-aware integration of machine learning and simulation to predict ribosome location profiles from RNA sequences.

bioRxiv : the preprint server for biology·2026

Same journal

A human-specific genetic modifier reconfigures large-scale cortical network dynamics underlying behavioral performance.

bioRxiv : the preprint server for biology·2026

Same journal

<i>Staphylococcus aureus</i> uses a eukaryotic-like uridyltransferase to make UDP-GlcNAc for cell wall synthesis.

bioRxiv : the preprint server for biology·2026

Same journal

Dynamic redistribution of eIF4F controls cap-dependent translation initiation.

bioRxiv : the preprint server for biology·2026

Same journal

When does additional information improve accuracy of RNA secondary structure prediction?

bioRxiv : the preprint server for biology·2026

Same journal

Normative brain-state trajectories reveal deviation from healthy aging in Alzheimer's disease.

bioRxiv : the preprint server for biology·2026

Same journal

Noradrenergic infraslow rhythm during sleep is the critical link between heart-rate dynamics and memory consolidation.

bioRxiv : the preprint server for biology·2026

查看所有相关文章

这项研究引入了一种新的算法,用于更准确的Hi-C数据分析,通过从基因组图中推断线性基因组. 这改善了Hi-C接触矩阵的构建,这对于理解染色体结构至关重要.

科学领域:

基因组学就是基因组学.
计算生物学计算生物学

背景情况:

三维 (3D) 染色体结构对于基因组功能至关重要.
高通量染色体构造捕获 (Hi-C) 测序彻底改变了3D基因组研究.
线性参考基因组由于遗传变异而限制了Hi-C准确性,特别是在癌症样本中.

结论:

这种新的算法有效地从Hi-C数据中推断出线性基因组.
推断基因组带来了改进的Hi-C接触矩阵,并减少了错误.
增强的矩阵更好地捕获拓相关的域和染色质循环.

更多相关视频

Capturing Chromosome Conformation Across Length Scales

Capturing Chromosome Conformation Across Length Scales

Published on: January 20, 2023

Generation of Genome-wide Chromatin Conformation Capture Libraries from Tightly Staged Early Drosophila Embryos

Generation of Genome-wide Chromatin Conformation Capture Libraries from Tightly Staged Early Drosophila Embryos

Published on: October 3, 2018

相关实验视频

Last Updated: Jul 10, 2025

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.

Published on: May 6, 2010

Capturing Chromosome Conformation Across Length Scales

Capturing Chromosome Conformation Across Length Scales

Published on: January 20, 2023

Generation of Genome-wide Chromatin Conformation Capture Libraries from Tightly Staged Early Drosophila Embryos

Generation of Genome-wide Chromatin Conformation Capture Libraries from Tightly Staged Early Drosophila Embryos

Published on: October 3, 2018