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Aging

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...

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Updated: Jul 10, 2025

Author Spotlight: Exploring Sex-Specific Glial Signatures and Therapeutic Leads for Alzheimer's Disease

Author Spotlight: Exploring Sex-Specific Glial Signatures and Therapeutic Leads for Alzheimer's Disease

Published on: May 20, 2024

在老化的人类大脑中单细胞转录和基因组变化.

Ailsa M Jeffries¹, Tianxiong Yu², Jennifer S Ziegenfuss¹

¹Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.

bioRxiv : the preprint server for biology

|November 21, 2023

概括

此摘要是机器生成的。

人类大脑衰老涉及到细胞变化,DNA修复和基本基因表达的下降. 神经发育基因在婴儿中突出,而神经元特异性基因保持稳定.

科学领域:

神经科学是一个神经科学.
基因组学就是基因组学.
细胞生物学细胞生物学

背景情况:

衰老导致细胞损伤和组织间的失调.

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Fluorescence-Activated Nuclei Negative Sorting of Neurons Combined with Single Nuclei RNA Sequencing to Study the Hippocampal Neurogenic Niche

Fluorescence-Activated Nuclei Negative Sorting of Neurons Combined with Single Nuclei RNA Sequencing to Study the Hippocampal Neurogenic Niche

Published on: October 20, 2022

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

相关实验视频

Last Updated: Jul 10, 2025

Author Spotlight: Exploring Sex-Specific Glial Signatures and Therapeutic Leads for Alzheimer's Disease

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Published on: May 20, 2024

Fluorescence-Activated Nuclei Negative Sorting of Neurons Combined with Single Nuclei RNA Sequencing to Study the Hippocampal Neurogenic Niche

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Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

了解衰老人类大脑中的转录和基因组变化至关重要.

结论:

在转录组和基因组层面阐明了人类大脑衰老的关键方面.
突出了整个生命中遗传和表达变化之间的动态相互作用.