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Updated: Jul 10, 2025

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在老化的人类大脑中单细胞转录和基因组变化

Ailsa M Jeffries¹, Tianxiong Yu², Jennifer S Ziegenfuss¹

¹Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.

bioRxiv : the preprint server for biology

|November 21, 2023

概括

人类大脑衰老涉及到细胞变化,DNA修复和基本基因表达的下降. 神经发育基因在婴儿中突出,而神经元特异性基因保持稳定.

科学领域:

神经科学是一个神经科学.
基因组学就是基因组学.
细胞生物学细胞生物学

背景情况:

衰老导致细胞损伤和组织间的失调.
了解衰老人类大脑中的转录和基因组变化至关重要.

结论:

在转录组和基因组层面阐明了人类大脑衰老的关键方面.
突出了整个生命中遗传和表达变化之间的动态相互作用.

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