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相关概念视频

Genome Annotation and Assembly03:36

Genome Annotation and Assembly

18.9K
The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
18.9K
GTPases and their Regulation02:14

GTPases and their Regulation

8.4K
Guanine nucleotide-binding proteins (G-proteins), also known as GTPases, are a superfamily of proteins that regulate many cellular processes, such as cell signaling, vesicular transport, and the regulation of cell shape and motility. Mutation or dysfunction of these proteins can lead to disease. There are around 40,000 known G-proteins that can broadly be classified into two groups ‒  small G-proteins consisting of a single domain and large multi-domain G-proteins.
Large G-proteins,...
8.4K
Tagging and Fusion Proteins01:24

Tagging and Fusion Proteins

6.7K
Proteins are involved in several cellular processes and biochemical reactions. Analyzing a specific protein of interest requires it to be isolated from the other proteins in the cell. This is achieved by overexpressing the specific gene in a suitable host to produce large quantities of the target protein. A tag or label is recombined with the gene to produce a fusion protein containing the target protein and the tag. The tags on these fusion proteins can then be used for easy detection and...
6.7K
GPCRs Regulate Adenylyl Cylase Activity01:09

GPCRs Regulate Adenylyl Cylase Activity

5.6K
Some GPCRs transmit signals through adenylyl cyclase (AC), a transmembrane enzyme. AC helps synthesize second messenger cyclic adenosine monophosphate (cAMP). AC catalyzes cyclization reaction and converts ATP to cAMP by releasing a pyrophosphate. The pyrophosphate is further hydrolyzed to phosphate by the enzyme pyrophosphatase, which drives cAMP synthesis to completion. However, cAMP is rapidly degraded to 5′ AMP by the enzymes phosphodiesterase (PDE), preventing overstimulation of...
5.6K
G Protein-coupled Receptors01:15

G Protein-coupled Receptors

12.1K
G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
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相关实验视频

Updated: Jul 10, 2025

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
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A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

Published on: May 22, 2018

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在Reactome策划过程中使用ChatGPT.

Krishna Tiwari1,2, Lisa Matthews3, Bruce May4

  • 1European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK.

bioRxiv : the preprint server for biology
|November 21, 2023
PubMed
概括
此摘要是机器生成的。

像ChatGPT这样的生成人工智能,在Reactome策划中显示出对自动化生物途径数据收集和注释的承诺. 这项研究探讨了它的效率和挑战,旨在改善蛋白质到通路的关联.

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A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information
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A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research
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相关实验视频

Last Updated: Jul 10, 2025

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
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A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

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A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information
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A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research
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科学领域:

  • 生物信息学是一种生物信息学.
  • 人工智能在生物学中的应用
  • 路径策划策划 路径策划

背景情况:

  • 包括ChatGPT在内的生成AI正在迅速发展.
  • 在生物路径策划中手动收集和注释数据是劳动密集的.
  • 反应体是通路信息的重要资源.

研究的目的:

  • 探索ChatGPT在Reactome的数据收集和注释中的实用性.
  • 开发一个自动化或半自动化框架来收集路径信息.
  • 为了提高效率和准确性,将ChatGPT生成的注释与手动策划进行比较.

主要方法:

  • 使用ChatGPT/GPT4进行路径注释和丰富,并与手动策划并行.
  • 对Reactome数据采用了以反应为中心的方法.
  • 对人工智能生成的信息与手动提取的信息进行了比较分析.
  • 确定并描述了改进人工智能输出的方法.

主要成果:

  • 聊天GPT在解决注释差距方面展示了有希望的功能.
  • 识别了使用人工智能用于Reactome策划的固有挑战.
  • 开发了改进人工智能输出的准确性和详细性的方法.
  • 促进了对人工智能辅助与手动策划的比较评估.

结论:

  • 生成型人工智能,特别是ChatGPT,提供了简化Reactome策划的潜力.
  • 半自动化框架可以提高效率和蛋白质与路径的关联.
  • 为了在生物数据策划中强大的人工智能集成,需要进一步的改进和验证.