在学龄儿童中,甲酸盐,乙氨基基和空气过敏原敏感性之间的关联
Jeongsik Yi1, Ho-Sang Shin2, Man Yong Han3
1Department of Emergency Medicine, Gumi CHA Medical Center, CHA University, Gumi, Korea.
Journal of Korean medical science
|November 21, 2023
概括
儿童暴露于甲酸盐与更高的乙氨基酸细胞数量有关,这表明炎症. 减少塑料容器的使用可能会降低甲酸盐的暴露,并防止相关的免疫反应.
科学领域:
- 环境健康 环境健康
- 儿科免疫学 儿科免疫学
- 毒理学 毒理学 毒理学
背景情况:
- 酸盐和双A (BPA) 是内分泌干扰化学物质,与儿童免疫疾病有关.
- 调查了COVID-19大流行期间与空气过敏原敏感化和乙氨基基细胞数量相关的尿甲酸和BPA水平.
研究的目的:
- 评估学童尿甲酸和BPA水平的区域差异.
- 为了检查甲酸盐暴露,空气过敏原敏感化和氨酸细胞计数之间的关联.
主要方法:
- 从203名学童 (7至10岁) 的尿样中分析了BPA,四种高分子量甲酸盐 (Σ4HMWP) 和三种低分子量甲酸盐 (Σ3LMWP).
- 还测量了总乙酸细胞计数,皮肤间流失的水分 (TEWL) 和皮肤刺伤测试结果.
主要成果:
- 工业集团的塑料容器使用率更高, Σ3LMWP 水平明显更高 (P < 0.001).
- 尿 Σ4HMWP 和 Σ3LMWP 在调整为辅因子 (P < 0.001) 后显著与增加的全氨基酸细胞数量相关.
- 酸盐代谢产物与空气过敏原敏感性或维生素D水平之间没有发现显著的关联.
结论:
- 暴露于甲酸盐与儿童的乙氨基酸细胞数量升高有显著关联,这表明与Th2细胞介导的炎症有联系.
- 减少塑料容器的使用可能是一个有效的策略,以最大限度地减少甲酸盐的暴露,并减轻儿童的相关炎症反应.
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