一种新的以基为基础的疫苗的基设计,用于对抗草1组过敏原
Dzhemal Moten1, Tsvetelina Batsalova1, Desislava Apostolova1
1Department of Developmental Biology, Faculty of Biology, Paisii Hilendarski University of Plovdiv, 24 Tsar Assen Str., 4000 Plovdiv, Bulgaria.
Advances in respiratory medicine
|November 21, 2023
概括
这项研究使用免疫信息学设计了一种针对草花粉过敏的基于表位组的新型疫苗. 候选疫苗在不触发IgE的情况下激活过敏患者的T细胞,显示出有效的草花粉过敏治疗的希望.
科学领域:
- 免疫学 免疫学 免疫学
- 过敏学 过敏学
- 计算生物学 计算生物学
背景情况:
- 过敏性疾病影响到30%的工业化人口.
- 草花粉过敏很普遍,其中1组和5组过敏原是主要的触发因素.
- 目前用于草花粉过敏的治疗方法可以通过新的疫苗策略来改进.
研究的目的:
- 使用免疫信息学设计一种潜在的以表位基为基础的针对草1组过敏原的疫苗.
- 为疫苗开发确定和分析T细胞和B细胞表位.
- 评估所选表观种群的种群覆盖面和结合性亲缘关系.
主要方法:
- 已知花粉过敏原表征的生物信息分析.
- 一个类序列的识别 (GTKSEVEDVIPEGWKADTSY).
- 通过分子对接的T细胞和B细胞表位的In silico预测和验证.
- 对来自患者的T细胞和IgE抗体进行了ex vivo测试.
主要成果:
- 一个合适的表位 (GTKSEVEDVIPEGWKADTSY) 被确定并分析.
- 选择的T细胞表位表现出高的全球和欧洲人口覆盖率 (高达98.20%和99.86%).
- 皮细胞对MHC分子具有强烈的结合亲和力,对人类IgE的亲和力较低,ex vivo测试证实T细胞激活,但不证实IgE的识别.
结论:
- 鉴定到的是以表位基草花粉过敏疫苗的有希望的候选人.
- 这项研究突出了普遍表征的潜力,用于开发有效的过敏疫苗.
- 需要进一步的体内研究来证实疫苗对草花粉过敏原的疗效.
关键词:
标志性表现物 (Epitopes) 是一种表现物.它们是ex vivo,ex vivo.草是一种过敏原.免疫信息学是一种免疫信息学.免疫疗法 免疫疗法在的中.基于的疫苗疫苗.对于花粉过敏 对于花粉过敏更多相关视频
06:34A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
Published on: June 4, 2017
10.0K
05:15Detection of Neutralization-sensitive Epitopes in Antigens Displayed on Virus-Like Particle VLP-Based Vaccines Using a Capture Assay
Published on: February 10, 2022
3.7K
相关概念视频
00:42Cross-reactivity
31.2K
Overview
31.2K
02:06Allergic Reactions
27.5K
Overview
27.5K
01:26Antigens Involved in Adaptive Immunity
502
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
Complete Antigens
Complete antigens possess both immunogenicity and...
502
01:10Antibody Structure
60.2K
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
60.2K