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在患有急性淋巴细胞白血病的儿童中,microRNA多态与甲索特酸诱导的毒性相关联

Vasiliki Karpa¹, Kallirhoe Kalinderi¹, Liana Fidani¹

¹Laboratory of Medical Biology-Genetics, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.

Hematology reports

|November 21, 2023

概括

微RNA变异可能会影响癌症患者的甲状腺素 (MTX) 毒性. 这项研究调查了这些遗传变异如何影响MTX的不良影响,从而有可能改善治疗个性化.

科学领域:

药物基因组学药物基因组学
分子生物学分子生物学
在瘤学瘤学.

背景情况:

甲甲酸 (MTX) 是治疗儿科急性淋巴细胞白血病 (ALL) 和其他癌症的重要化疗药物.
患者在MTX药理动力学/药理动力学上的变化会导致毒性和粘膜炎等不良事件.
MTX运输基因中的遗传变异与毒性有关,之前的研究重点是单核酸多态 (SNP).

研究的目的:

调查微RNA (miRNA) 变体在调解甲状腺酸盐 (MTX) 副作用中的作用.
探索miRNA多态性对MTX药理学和毒性的影响.

主要方法:

关于miRNA多态性和MTX毒性的最新文献的综述.
对将miRNA调节与药物运输,新陈代谢和基因表达联系起来的研究进行分析.
专注于特定miRNA变体与MTX相关不良事件之间的关联.

主要成果:

新出现的证据强调了miRNAs在调节药物反应和毒性的重要作用.
米RNA多态性代表了对MTX不良影响的新研究领域.
研究表明miRNA变体与MTX诱导的毒性之间存在潜在联系.

结论:

密RNA变异是理解和预测MTX毒性的有希望领域.
对miRNA多态性的进一步研究可能会导致个性化的MTX剂量策略.
研究miRNA的作用可能有助于减轻不良事件并改善癌症治疗结果.

关键词:

急性淋巴细胞白血病急性淋巴细胞白血病甲基特雷克萨酸盐的使用方法微RNAs 是一个微型RNA.儿科儿科儿科药物遗传学药物遗传学毒性的毒性毒性的毒性

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