血清激素毒性与线化物-血清激素剂联合治疗的关联:系统性审查和元分析
Savanna SanFilippo1,2, Jacques Turgeon3, Veronique Michaud3
1Robert Wood Johnson University Hospital Somerset, Somerville, NJ 08876, USA.
Pharmacy (Basel, Switzerland)
|November 21, 2023
概括
莱因佐利德 (LZD) 增加了胺毒性风险,当与胺药物结合使用. 使用多种血清激素药物显著增加了这种风险,需要仔细评估利益风险.
科学领域:
- 药理学 药理学是指药理学的学科.
- 临床药房 临床药房
- 药品安全 药品安全
背景情况:
- 线化物 (LZD) 与胺毒性 (ST) 有关,原因是与胺激素药物的相互作用.
- 缺乏关于同时使用LZD的ST发病率和风险因素的确数据.
研究的目的:
- 评估在接受LZD治疗的患者中,与LZD单独治疗相比,接受LZD治疗的患者中,ST的发生率.
- 根据同时服用的血清激素药物的数量来比较ST发病率.
主要方法:
- 从PubMed,Scopus和谷歌学者 (2000-2023) 获取的研究的元分析.
- 包括五项高质量的研究,包括6025名LZD单疗法与组合治疗分析的6025名患者.
- 分析了四项涉及2501名患者的研究,比较了一种与多种带有LZD的血清激素药物.
主要成果:
- 同时服用血清激素药物增加了ST风险 (OR 1.78,CI [1.04,3.02]),GRADE确定性低.
- 使用两种或多种血清激素药物与使用一种药物相比,显著增加了ST风险 (OR 5.18,CI [1.05,25.49]),具有中等等级确定性.
结论:
- 同时服用的血清激素药物的数量是服用linezolid的患者中血清激素毒性的潜在危险因素.
- 对于需要线索利德和血清激素药物的患者,临床决策必须仔细权衡风险与益处,考虑到相互作用药物的数量.
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