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在甲状腺恶性瘤中[⁶⁸Ga]Ga-PSMA成像的临床意义和应用价值

Yu Yue Feng¹, Yang Rui Shi¹, Zhu Xia¹

¹Department of Nuclear Medicine, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Chongqing, PR China.

|November 21, 2023

概括

前列腺特异性膜抗原 (PSMA) 成像显示出对抗抗性甲状腺癌的前景. 虽然PSMA表达随着差异化较低而增加,但吸收与瘤负担相关,而不是差异化本身,这表明更广泛的临床实用性.

科学领域:

在瘤学瘤学.
核医学是一种核医学.
分子成像学分子成像学

背景情况:

差异化甲状腺癌 (DTCs) 失去吸收 (约. 5%) 只有有限的治疗选择.
前列腺特异性膜抗原 (PSMA) 成像正在探索对耐火DTC,但数据异质.
需要进一步的研究来澄清PSMA在DTC管理中的应用价值.

研究的目的:

研究PSMA在差异化甲状腺癌中的表达和成像效用.
在DTC中评估PSMA摄入量与瘤特征之间的相关性.

主要方法:

西方斑块和PCR测试用于评估PSMA在细胞系中的表达.
[68Ga]Ga-PSMA吸收实验和小动物成像.
来自DTC患者的临床和放射学数据的分析 (试验注册:2021-669).

主要成果:

与差异化类型相比,差异化甲状腺癌的PSMA表达显著高于差异化类型 (P <0.01).
[68Ga]Ga-PSMA成像吸收与瘤负担相关,由2-[18F]FDG吸收 (P = 0.01) 和铁血球蛋白 (Tg) 水平 (P = 0.002) 表示.
在[68Ga]Ga-PSMA摄入量和甲状腺癌分化程度之间没有发现显著的关联.

结论:

随着甲状腺癌分化减少,PSMA表达增加.
DTC患者的PSMA吸收受瘤代谢和负担的影响,而不仅仅是差异化.
这些发现凸显了PSMA在治疗甲状腺癌方面的临床意义和应用潜力.

关键词:

前列腺特异性膜抗原; 甲状腺癌; 瘤负担

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