在印度18-45岁的成年人中,与无法解释的突然死亡相关的因素 - 一个多中心匹配病例控制研究
Manickam Ponnaiah1, Tarun Bhatnagar2, Rizwan Suliankachi Abdulkader1
1Division of Online Courses, Chennai, Tamil Nadu, India.
The Indian journal of medical research
|November 21, 2023
概括
接种COVID-19疫苗并没有增加印度年轻人突然死亡的原因. 过去COVID-19住院和生活方式行为等因素与风险增加有关.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 心脏病学 心脏病学
背景情况:
- 事报告表明,COVID-19感染/接种疫苗和印度年轻成年人的突然死亡之间存在联系.
- 为了调查这些关联,启动了一项多中心匹配病例控制研究.
研究的目的:
- 确定与印度18-45岁明显健康个体突然死亡相关的因素.
- 调查COVID-19疫苗接种和感染在这些事件中的作用.
主要方法:
- 一个多中心匹配的病例控制研究,涉及印度各地的47家三级医院.
- 病例:年龄在18-45岁之间,没有已知的并发病症的个体,突然和无法解释的死亡.
- 控制组:每例年龄,性别和邻居相匹配的四个人. 收集关于COVID-19状态,疫苗接种,家族病史和生活方式因素的数据.
主要成果:
- 分析了729个病例和2916个对照组.
- 接种COVID-19疫苗 (至少一剂) 与突然不明原因死亡的几率较低有关 (aOR:0.58). 两个剂量显示出类似的保护作用 (aOR:0.51).
- 与增加几率积极相关的因素包括过去的COVID-19住院治疗,家族突发死亡病史,过度饮酒,娱乐性药物使用和剧烈的体力活动.
结论:
- 接种COVID-19疫苗与年轻人突然死亡的风险增加无关.
- 过去的COVID-19住院和特定的生活方式行为被确定为突然不明原因死亡的危险因素.
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