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在酒精性肝病中,肠道微生物群迅速激活自然杀手细胞
Jung A Eom1, Jin-Ju Jeong1, Sang Hak Han2
1Institute for Liver and Digestive Diseases, Hallym University, Chuncheon, Republic of Korea.
益生菌菌株,Phocaeicola dorei和Lactobacillus helveticus,改善了肝炎和自然杀手 (NK) 细胞活性在酒精性肝病 (ALD) 模型中. 这些发现表明,肠道微生物组可以调节免疫细胞以改善ALD.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 肝病学 肝病学是一种肝病学.
背景情况:
- 肝脏是天生的免疫细胞的宿主,包括自然杀手 (NK) 细胞,这些细胞对免疫反应至关重要.
- 酒精消费导致免疫细胞功能障碍,特别影响酒精性肝病 (ALD) 中的NK细胞.
- 有限的数据存在于肠道微生物组和免疫细胞在ALD发病过程中的相互作用.
研究的目的:
- 研究特定益生菌菌株对ALD患者NK细胞的影响.
- 在实验ALD模型中评估Phocaeicola dorei和Lactobacillus helveticus的治疗潜力.
主要方法:
- 从对照组,酒精性肝炎和酒精性肝硬化患者收集了125个人类血液样本进行流细胞计.
- 使用了C57BL/6J小鼠,分为正常小鼠,乙醇养小鼠和两组乙醇养小鼠,接受P. dorei或L. helveticus.
- 在人类和小鼠样本中分析了淋巴细胞群和NK细胞活性标志物 (例如NKp46,CD56dimCD16+).
主要成果:
- 在ALD患者中NK细胞的频率有所变化:在酒精性肝炎中增加,在酒精性肝硬化中减少.
- 在ALD患者中,NK细胞受体NKp46的表达被改变,而细胞毒性CD56dimCD16+NK细胞在肝硬化中减少.
- 在小鼠中服用益生菌可降低肝炎,改善肠道屏障功能,增强NK细胞活性.
结论:
- 肠道微生物群,通过P. dorei和L. helveticus等益生菌,可能在改善ALD方面发挥作用.
- 益生菌可以调节免疫细胞功能,为ALD提供潜在的治疗策略.
- 需要进一步的研究来阐明肠道微生物群影响ALD进展的机制.
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