基的密度功能理论引导的照片触发的抗癌活性 (II) 复合物
Rajesh Kushwaha1, Virendra Singh2, Silda Peters3
1Department of Chemistry, Indian Institute of Technology (BHU), Varanasi, Uttar Pradesh 221005, India (Email: samya.chy@itbhu.ac.in).
The journal of physical chemistry. B
|November 21, 2023
概括
这项研究增强了黄素的功效.
科学领域:
- 协调化学 协调化学
- 摄影化学的使用.
- 癌症治疗方法 癌症治疗方法
背景情况:
- 光动力疗法 (PDT) 是一种有前途的癌症治疗方法,副作用较少.
- 黄素的临床使用受到生物可用性差的限制.
- 开发新的光敏感剂对于推动PDT至关重要.
研究的目的:
- 通过Zn (II) 复合,增强黄素的生物可用性和PDT疗效.
- 为了合成和表征新型Zn(II) - 黄素复合物.
- 为了研究改进的光敏剂的结构-活性关系.
主要方法:
- 用N^N和O^O连接体合成和表征Zn(II) 复合物.
- 用于结构确定的X射线晶体学.
- 光物理研究,TD-DFT计算和单点氧气生成试验.
- 使用MCF-7癌细胞进行体外研究.
- 分子对接和动力学模拟.
主要成果:
- 合成和描述了2和3的Zn(II) 复合物.
- 综合体2和3展示了高效的可见光触发单点氧气生成.
- 这些复合体在光照照射下在癌细胞中表现出强烈的亡性抗癌活性.
- 分子对接揭示了与caspase-9和p-53强烈的结合亲和关系,这对亡至关重要.
结论:
- 复合物Zn (II) - 黄素显著提高了生物可用性和PDT的疗效.
- 综合体2和3是有效的可见光光敏化剂,具有抗癌性质.
- 这些复合物通过与关键蛋白质如caspase-9和p-53相互作用来诱导亡.
![Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F60786.jpg&w=3840&q=50)
相关概念视频
02:59Biological Effects of Radiation
All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they produce ions...
02:53Adaptive Mechanisms in Cancer Cells
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
02:27Base-pairing and DNA Repair
Erwin Chargaff’s rules on DNA equivalence paved the way for the discovery of base pairing in DNA. Chargaff’s rules state that in a double-stranded DNA molecule,
02:53Adaptive Mechanisms in Cancer Cells
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
01:25Mutagenicity and Carcinogenicity
Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...