合体-GNN:联合合体学习与图形神经网络用于疾病模块发现和分类
Bastian Pfeifer1, Hryhorii Chereda2, Roman Martin3
1Institute for Medical Informatics, Statistics and Documentation, Medical University Graz, Graz 8036, Austria.
Bioinformatics (Oxford, England)
|November 21, 2023
概括
使用Ensemble-GNN进行联合学习,可在分布式患者数据上使用图形神经网络 (GNN) 促进协作医学研究. 这种方法从蛋白质-蛋白质相互作用网络构建预测模型,而不集中敏感的奥米克信息.
科学领域:
- 计算生物学 计算生物学
- 生物信息学是一种生物信息学.
- 机器学习在医学中的应用
背景情况:
- 联合学习通过分析分布式数据而无需中央聚合,使多中心医疗协作成为可能.
- 图形神经网络 (GNN) 非常适合生物医学数据,例如蛋白质-蛋白质相互作用 (PPI) 网络,代表患者的奥米克特征.
研究的目的:
- 引入Ensemble-GNN,这是一个用于部署联合,基于集团的GNN的Python包.
- 使用具有多种节点特征的PPI网络 (例如,基因表达,DNA甲基化) 快速开发预测模型.
主要方法:
- 在 Python 中开发和实现 Ensemble-GNN 软件包.
- 利用联合学习原则,在分散的数据上训练GNN模型.
- 集成各种omics数据类型作为PPI网络中的节点特征.
主要成果:
- 展示Ensemble-GNN使用联合GNN构建预测模型的能力.
- 使用来自癌症基因组图谱 (TCGA) 的公开数据集提出的示范结果,其中包括981名患者和8469个基因.
- 成功应用了分析复杂生物医学图形数据的软件包.
结论:
- Ensemble-GNN为医学中的联合GNN分析提供了一个强大的框架.
- 该套餐通过利用分布式学习来促进对敏感患者数据的协作研究.
- Ensemble-GNN支持整合多omics数据,以在癌症研究中增强预测建模.
更多相关视频
相关概念视频
Classification of Illness
7.5K
The meaning of illness is individualized to each person who experiences an alteration in health. In contrast, disease is a medical term indicating a pathological change in the structure and function of the body or mind. It is a condition that has specific symptoms and boundaries.
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe...
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe...
7.5K
Protein Networks
2.3K
2.3K
Genome-wide Association Studies-GWAS
13.5K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
13.5K
Neural Circuits
1.3K
Neural circuits and neuronal pools are two of the main structures found in the nervous system. Neural circuits are networks of neurons that work together to carry out a specific task or process. They consist of interconnected neurons and glial cells, which provide structural and metabolic support.
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
1.3K
Classification of Neurotransmitters
3.0K
Neurotransmitters play a crucial role in the communication between neurons in the autonomic nervous system. Neurons in the autonomic nervous system can be cholinergic or adrenergic depending on the neurotransmitters synthesized. Cholinergic neurons use acetylcholine as their primary neurotransmitter. This includes all the preganglionic fibers of the sympathetic and pre- and postganglionic fibers of the parasympathetic nervous systems. In addition, neurons of the somatic nervous system also use...
3.0K
Principles of Disease Surveillance
104
Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...
104


