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Updated: Jul 10, 2025

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

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在宏观循环中曲的π-结合:非对称的螺旋hexenolides A和B的总合成

Lian-Dong Guo1, Yanting Wu1, Xin Xu1

  • 1Department of Chemistry, The Hong Kong University of Science and Technology, Clearwater Bay, Kowloon, Hong Kong, 999077, China.

Angewandte Chemie (International ed. in English)
|November 21, 2023
PubMed
概括

研究人员首次实现了罕见的抗癌螺旋hexenolides A 和 B 的非对称总合成. 这一突破克服了与曲 π 结合形成应变宏循环的挑战,为药物化学发展铺平了道路.

关键词:
结合方式 结合方式宏观循环化过程中的转化论 (Metathesis) 是一种转化论.自然产品 自然产品总的综合 总的综合

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