免疫检查点和检查点抑制剂在炎症性神经病变中的协同作用:含义和机制
Aritrani Sarkar1, Madhu Nagappa2, Saikat Dey1
1Department of Human Genetics, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India.
免疫检查点抑制剂 (ICI) 彻底改变了癌症治疗,但可以导致严重的神经损伤,称为免疫相关不良反应 (irAEs). 了解ICI诱导的炎症性神经病变背后的机制对于患者的安全至关重要.
科学领域:
- 免疫学和神经科学
- 瘤学和自身免疫系统
背景情况:
- 免疫检查点调节免疫平衡;它们的干扰导致自身免疫性疾病和癌症.
- 免疫检查点抑制剂 (ICI) 是有效的癌症疗法,但会引起与免疫相关的不良反应 (irAEs).
- 炎症性神经病变,如吉兰-巴雷综合征 (GBS) 和慢性炎症性脱细化多基基隆神经病变 (CIDP),正在挑战具有显著残疾的irAEs.
研究的目的:
- 对ICI诱导的炎症性神经病变背后的机制的现有证据进行审查.
- 讨论潜在的风险因素及其在这些不良影响发展中的作用.
- 提出可测试的假设,关于由免疫疗法触发的神经炎症的发病.
主要方法:
- 文献审查和现有证据的综合.
- 讨论神经炎症的拟议机械路径.
- 关于遗传和免疫学风险因素的假设的制定.
主要成果:
- 通过ICI引发炎症性神经病变的确切机制在很大程度上是未知的.
- 自免疫反应和炎症被认为是关键的风险机制.
- 预先存在的风险因素,遗传变异,自身抗体和T细胞激活对ICI诱导的神经病变的贡献需要进一步调查.
结论:
- ICI治疗具有显著的瘤益处,但存在严重神经性IRAE的风险.
- 需要进一步的研究来阐明导致ICI诱导的炎症性神经病变的因素的复杂相互作用.
- 开发这些irAEs的预测和预防策略对于优化癌症免疫治疗至关重要.
更多相关视频
08:17A Human Peripheral Blood Mononuclear Cell PBMC Engrafted Humanized Xenograft Model for Translational Immuno-oncology I-O Research
Published on: August 15, 2019
06:43Increased Recovery Time and Decreased LPS Administration to Study the Vagus Nerve Stimulation Mechanisms in Limited Inflammatory Responses
Published on: March 29, 2017
相关概念视频
Combined Effects of Drugs: Synergism
Such synergistic combinations...
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Interactions Between Signaling Pathways
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Inflammatory Response
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Combined Effects of Drugs: Antagonism
The most common type is receptor antagonism, where one drug acts as an antagonist to block the effects of another drug by...
