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TRIM基因的进化模式突出显示了哺乳动物抗病毒效应器的进化可塑性

Alexandre P Fernandes^1,2,3, Molly OhAinle⁴, Pedro J Esteves^1,2,3

¹CIBIO, Centro de Investigação em Biodiversidade e Recursos Genéticos, InBIO Laboratório Associado, Campus de Vairão, Universidade do Porto, Vairão, Portugal.

Genome biology and evolution

|November 21, 2023

概括

哺乳动物的先天免疫力依赖于TRIM基因,如TRIM5和TRIM22,用于逆转录病毒的限制. 这些关键的免疫基因显示了各种各样的进化模式,反映了对抗病毒威胁的适应性策略.

科学领域:

免疫学免疫学免疫学
进化生物学进化生物学
基因组学就是基因组学.

背景情况:

天生的免疫系统通过相互作用的蛋白质提供了对病原体的第一个防御.
E3-ubiquitin结合酶三方基因 (TRIM) 基因家族的基因对于先天免疫力至关重要,限制逆转录病毒.
TRIM5和TRIM22是哺乳动物抗逆转录病毒限制的关键因素,特别与艾滋病毒限制有关.

研究的目的:

为了提供TRIM5和TRIM22基因在eutherian哺乳动物的全面进化分析.
为了研究TRIM基因积累在哺乳动物种类中的不同模式.
了解哺乳动物免疫系统对抗逆转录病毒的适应策略.

主要方法:

在TRIM基因中积极选择的分析.
对大量哺乳动物基因组进行比较基因组分析.
在eutherians中检查TRIM基因演变的研究.

主要成果:

积极选择分析证实了TRIM基因在某些哺乳动物群体中的重要性.
许多哺乳动物物种缺乏TRIM5和TRIM22基因.
在哺乳动物类别中,TRIM基因积累模式显著不同.
有证据表明,鱼免疫系统的进化可塑性适应了对抗逆转录病毒.

结论:

在哺乳动物类别中,TRIM限制因素的演变是不相似的.
哺乳动物的免疫系统在对抗逆转录病毒感染方面表现出适应性和特异性进化.
在TRIM基因存在和演变中的差异突出了不同的宿主-病原体相互作用策略.

关键词:

这就是TRIM TRIM.在 TRIM5 中,免疫遗传学免疫遗传学阳性选择是一种积极的选择.限制因素是限制因素.复原病毒的演化过程

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