进化和预后价值的左心室变形和心肌工作参数在 transthyretin 粉状心肌病
Jerome Antonelli1, Antoine Neveu1, Wojciech Kosmala2
1Cardiologie, CHU de RENNES, LTSI UMR1099, INSERM, Université de Rennes-1, Rennes, France.
European heart journal. Cardiovascular Imaging
|November 21, 2023
概括
通过使用多室菌株评估,可以改进野生类型的西氨基化心肌病 (ATTR-CM) 监测. 心肌工作参数为ATTR-CM患者提供了增强的临床风险分层.
科学领域:
- 心脏病学 心脏病学
- 心血管成像 - 心血管成像
- 生物医学工程 生物医学工程
背景情况:
- 越来越多的人认识到野生类型的跨氨酸粉样性心肌病 (ATTR-CM),但预后仍然具有挑战性.
- 通过心声回声学评估的心肌工作,提供了心肌损伤的敏感特征.
- 目前评估ATTR-CM程度和预后的方法需要改进.
研究的目的:
- 为了研究ATTR-CM患者的心肌变形和工作参数.
- 评估这些参数随着时间的推移而发生的变化.
- 评估心肌工作和应变参数的预后价值.
主要方法:
- 对113名野生型ATTR-CM患者的临床,心电图,生物学和心声学数据的分析.
- 基线和18个月随访数据的比较.
- 多变量分析以确定死亡率和心力衰竭住院治疗的预后因素.
主要成果:
- 在18个月内,左心房应变 (LASRES),左心室纵向应变,全球工作指数 (GWI) 和全球建设性工作的显著下降.
- 左心室壁厚度增加,而喷射率和右心室自由壁应变 (FWS) 保持稳定.
- 基线GWI,全球浪费工作 (GWW),FWS和LASRES是死亡和心力衰竭住院治疗的重要预测因素.
结论:
- 多室菌株评估可以增强ATTR-CM患者监测.
- 心肌工作参数为ATTR-CM中的临床风险分层提供了宝贵的见解.
- 对心肌工作和应变的回声心脏学评估对管理ATTR-CM具有前景.
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