肠道微生物群丰富和多样性的关联与人口样本中的客观和主观睡眠测量
Elizabeth A Holzhausen1, Paul E Peppard2, Ajay K Sethi2
1Department of Integrative Physiology, University of Colorado, Boulder, CO, USA.
Sleep
|November 21, 2023
概括
睡眠质量和变化不佳与下肠道微生物群多样性和成分变化有关. 这凸显了生活方式因素 (如睡眠) 如何影响肠道健康.
科学领域:
- 微生物组研究 微生物组研究
- 睡眠科学 睡眠科学
- 人类健康 人类健康 人类健康
背景情况:
- 肠道微生物群的改变与各种健康状况有关.
- 新出现的证据表明,睡眠模式和肠道微生物组合之间存在联系.
研究的目的:
- 为了研究睡眠测量和肠道微生物组组成之间的关联.
- 分析睡眠的数量和质量与肠道微生物的多样性和丰富性相关.
主要方法:
- 利用了来自威斯康星州健康调查的数据 (N=720).
- 评估了α多样性 (Chao1,Shannon,Inverse Simpson) 和β多样性 (Bray-Curtis) 的情况.
- 采用线性混合效应模型,PERMANOVA和负二项式模型来分析关联.
主要成果:
- 睡眠变化增加,睡眠开始后醒来,睡眠质量差与微生物组丰富性和多样性减少相关.
- 睡眠变量显著影响了β-多样性.
- 特定的肠道种类的相对丰富性与睡眠时间的变化,延迟,效率和质量有关.
结论:
- 睡眠的数量和质量似乎与肠道微生物组合有关.
- 研究结果支持可修改的健康习惯,如睡眠,对人类肠道微生物群的影响.
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