合成和表征4-二甲与基于ZnO的纳米颗粒用于生物医学应用
Thangavelu Indumathi1, Inbavalli Kumaresan2, Jagadeesh Suriyaprakash3
1Department of Chemistry, CHRIST (Deemed to be University), Bangalore, Karnataka, India.
Journal of basic microbiology
|November 21, 2023
概括
用4-甲 (4NBZnO NPs) 修改的氧化纳米颗粒 (ZnO NPs) 具有强大的抗菌和抗癌作用. 这些纳米粒子有效诱导细胞亡,并通过增加活性氧物种 (ROS) 来降低黑色素瘤细胞的活力.
科学领域:
- 纳米技术纳米技术
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
背景情况:
- 皮肤癌是全球普遍存在的健康问题.
- 氧化纳米颗粒 (ZnO NPs) 具有治疗性质,包括抗氧化,抗菌,抗炎和抗癌作用.
- 纳米粒子为治疗各种皮肤疾病提供了一个有希望的途径.
研究的目的:
- 为了合成和表征4-二甲改性氧化纳米颗粒 (4NBZnO NPs).
- 为了评估4NBZnONP的抗菌活性.
- 研究4NBZnONP对黑色素瘤细胞亡,活力,线粒体膜潜力 (MMP),活性氧物种 (ROS) 生产和细胞粘附的影响.
主要方法:
- 使用各种技术合成和描述4NBZnONP.
- 对测试的病原体进行抗菌检测.
- 在体外对SK-MEL-3黑色素瘤细胞进行研究,以评估细胞活力,MMP,ROS生成,细胞亡和细胞粘附.
主要成果:
- 合成的4NBZnONP显示出显著的抗菌特性.
- 用4NBZnONP治疗抑制了黑色素瘤细胞中的细胞活力和MMP,以剂量依赖的方式.
- 4NBZnO NPs诱导了剂量依赖的ROS产量的增加,导致细胞亡的增加和细胞粘附的减少.
结论:
- 4NBZnONP表现出有前途的抗菌和抗癌活性.
- 抗癌效应通过ROS生成,诱导亡,减少黑色素瘤细胞的细胞活力和粘附来调节.
- 这些发现表明,4NBZnO NPs作为治疗皮肤癌治疗的治疗剂的潜力.
关键词:
4 - - 尼托二甲ZnO ZnO ZnO ZnO ZnO ZnO ZnO ZnO ZnO ZnO ZnO ZnO它具有抗菌活性,具有抗菌活性.这是一种抗癌药物.灭症 (apoptosis) 是一种死亡的过程.更多相关视频
06:54Formulation of Zinc-Based Nanomaterials using the Eucommia ulmoides Bark Extract and their Wound Healing Potential
Published on: December 27, 2024
412
11:16Preparation of Silver-Palladium Alloyed Nanoparticles for Plasmonic Catalysis under Visible-Light Illumination
Published on: August 18, 2020
5.5K
相关概念视频
01:20Electrophilic Aromatic Substitution: Nitration of Benzene
6.0K
The nitration of benzene is an example of an electrophilic aromatic substitution reaction. It involves the formation of a very powerful electrophile, the nitronium ion, which is linear in shape. The reaction occurs through the interaction of two strong acids, sulfuric and nitric acid.
6.0K
01:29Preparation of Amines: Reduction of Oximes and Nitro Compounds
3.7K
Oximes can be reduced to primary amines using catalytic hydrogenation, hydride reduction, or sodium metal reduction. The reduction of aliphatic and aromatic nitro compounds to primary amines takes place by either catalytic hydrogenation or by using active metals like Fe, Zn, and Sn in the presence of an acid.
Though catalytic hydrogenation can reduce nitrobenzenes, the reduction is nonselective in the presence of other functional groups. For instance, if nitrobenzene contains an aldehyde group,...
Though catalytic hydrogenation can reduce nitrobenzenes, the reduction is nonselective in the presence of other functional groups. For instance, if nitrobenzene contains an aldehyde group,...
3.7K