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营养指数和炎症参数对接受针对非小细胞肺癌免疫治疗的患者的影响
Hui-Ping Ding1, Yi-Qun Ling1, Wei Chen2
1Department of Nutrition, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Current problems in cancer
|November 21, 2023
概括
营养状况和炎症显著影响化学疗法和免疫疗法期间非小细胞肺癌 (NSCLC) 患者的生存率. 营养不良和较低的高级肺癌炎症指数 (ALI) 评分预测了较差的结果.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 营养科学 营养科学
背景情况:
- 非小细胞肺癌 (NSCLC) 的治疗通常涉及化疗和免疫疗法.
- 患者的预后可能受到各种因素的影响,包括营养状况和全身炎症.
研究的目的:
- 研究在接受联合化疗和免疫治疗的NSCLC患者的营养标志物,炎症指数和治疗结果之间的关联.
- 确定特定的营养和炎症因素,这些因素可以预测这个患者队伍的生存率.
主要方法:
- 用化疗和免疫疗法治疗的NSCLC患者的回顾性单中心分析.
- 营养指数的评估 (营养不良,肉,肉肥胖症) 和高级肺癌炎症指数 (ALI).
- 使用卡普兰-梅尔曲线和考克斯比例危险模型进行生存分析.
主要成果:
- 在营养不良,肉,肉性肥胖症和低ALI得分之间观察到显著的相关性,随着总生存率 (OS) 和无进展生存率 (PFS) 的减少.
- 低ALI得分和营养不良被确定为OS和PFS的独立预测因素.
- 统计学意义被确定为对应关系的p < 0.05和独立因子的p < 0.01.
结论:
- 营养状况和炎症标志物显著影响接受化疗和免疫治疗的NSCLC患者的预后.
- 纳入营养和炎症指数的评估可以帮助优化治疗策略并改善患者的治疗结果.
- 需要进一步的研究来阐明营养,炎症和癌症进展之间的复杂相互作用,以开发个性化治疗.
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