慢性偏头痛中视觉皮层的功能连接在药物戒断治疗前和后的慢性偏头痛
Veronica Mäki-Marttunen1, Dennis A Kies2, Judith A Pijpers2
1Cognitive Psychology Unit, Institute of Psychology, Leiden University, Leiden, The Netherlands; Leiden Institute for Brain and Cognition (LIBC), Leiden University, Leiden, The Netherlands.
NeuroImage. Clinical
|November 21, 2023
概括
从头痛药物中的急性戒断显著减少慢性偏头痛的频率. 成功治疗涉及视觉皮层功能连接的变化,提供了对偏头痛慢性化和可逆性的新见解.
科学领域:
- 神经科学是一个神经科学.
- 放射学 放射学是一门学科.
- 神经学 神经学
背景情况:
- 慢性偏头痛 (CM) 通常与药物过量使用有关.
- 药物的急性停用可以大大减少CM患者头痛的频率和严重程度.
- 在CM中,潜在的大脑网络及其对戒断的反应尚未得到充分理解.
研究的目的:
- 描述慢性偏头痛特有的内在功能连接 (FC) 模式.
- 为了确定CM中与成功的药物戒断治疗相关的FC变化.
- 探索治疗响应者和不响应者之间的基线FC差异.
主要方法:
- 休息状态功能性MRI (fMRI) 扫描在停药3个月之前和之后对99名CM患者进行.
- 四个对照组 (健康,偶发性偏头痛,慢性背痛,抑郁症) 进行了一次扫描.
- 双回归分析比较了全脑FC与10个休息状态网络之间的组和治疗响应者/不响应者之间的组.
主要成果:
- 与健康对照组相比,CM患者在几个静止状态网络中表现出改变的FC,特别是涉及视觉皮质.
- 这些FC变化与偶发性偏头痛,慢性疼痛和抑郁症的变化部分重叠,表明共享的神经通路.
- 响应者成功戒断与视觉皮层的FC减少有关,响应者与非响应者相比显示出明显的基线视觉皮层FC.
结论:
- 慢性偏头痛与功能连接的改变有关,特别是在视觉皮层内.
- 在CM中成功的药物戒断治疗与视觉皮层FC的正常化有关.
- 这些发现为偏头痛慢性化的可逆性提供了神经成像证据,并突出了视觉皮层的作用.
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