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Updated: Jul 10, 2025

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RNA结合蛋白AUF1/HNRNPD调节了SNCA转录的核出口,稳定性和翻译

Fedon-Giasin Kattan1,2, Pelagia Koukouraki1, Athanasios K Anagnostopoulos1

  • 1Center of Basic Research, Biomedical Research Foundation of the Academy of Athens (BRFAA), Soranou Efesiou 4, Athens 11527, Greece.

Open biology
|November 21, 2023
PubMed
概括

AUF1蛋白调节多个阶段的α-synuclein (SNCA),包括mRNA成熟,出口,稳定性和翻译. 这一发现通过控制SNCA表达,为帕金森病治疗提供了新的点.

关键词:
在AUF1/HNRNPD中使用.在RNA结合蛋白质中的RNA结合蛋白.这是SNCA的SNCA.已经死亡的enylation.核细胞质的穿运输转录后监管的规定.

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