响应pH的可注射多功能Pluronic F127/基于凝的水凝,用于治疗糖尿病伤口
Tian Zhang1, Xin Cheng1, Jingya Xiu1
1College of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
ACS applied materials & interfaces
|November 21, 2023
概括
一种装有黄素和微电机的新型水凝有效治疗糖尿病慢性伤口. 这种可注射材料可以自我愈合,响应pH值,并通过减少炎症和氧化应激来促进组织再生.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 伤口愈合 治愈 伤口愈合
背景情况:
- 由于持续的炎症和氧化应激,糖尿病慢性伤口存在重大挑战.
- 目前的治疗方法往往无法解决复杂的伤口环境.
研究的目的:
- 为糖尿病慢性伤口管理开发一种响应pH的,可注射的多功能水凝 (GCM微电机).
- 为了结合黄素的治疗性质和微电机用于反应性氧物种的清理.
主要方法:
- 使用凝和Pluronic F127含黄素的粒制造水凝 (CUR-FCHO).
- 包括基微电机用于生产气.
- 评估水凝的特性,包括自我愈合,可注射性,pH响应,抗菌活性和生物相容性.
- 在糖尿病小鼠伤口模型中评估治疗疗效.
主要成果:
- 该GCM水凝证明了自我愈合,可注射性和pH响应的药物释放.
- 水凝表现出固有的抗菌和强大的抗氧化特性.
- 在体内研究表明,糖尿病小鼠的伤口关闭得到改善,血管增强和原沉积增加.
结论:
- 开发的GCM微运动液凝是一种有前途的治疗策略,用于糖尿病慢性伤口.
- 水凝有效调节伤口微环境,促进组织再生.
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