多环芳暴露对线粒体DNA复制号的影响
Sun-Haeng Choi1,2, Bolormaa Ochirpurev3, Hwa Yeong Jo3
1Department of Occupational and Environmental Medicine, Chungbuk National University Hospital, Cheongju, Republic of Korea.
Human & experimental toxicology
|November 21, 2023
概括
空气中的多环芳 (PAH) 暴露会影响健康. 这项研究发现,非总PAH,而是尼特烯代谢物与线粒体DNA拷贝数 (mtDNAcn) 的变化有关,这表明线粒体受损.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 线粒体生物学 线粒体生物学
背景情况:
- 空气中的多环芳 (PAHs) 与不良健康影响有关.
- 暴露可以诱导氧化应激和线粒体损伤,由线粒体DNA复制数 (mtDNAcn) 的变化表明.
研究的目的:
- 调查大气中的[a]烯 (BaP) 和1-尼托烯 (1-NP) 暴露与成人mtDNAcn之间的关联.
- 探索特定的PAH和酸代谢物在线粒体功能障碍中的作用.
主要方法:
- 研究包括来自韩国州的108名成年人.
- 测量了大气中的BaP和1-NP,尿液中的代谢物 (6-OHNP,1-NAAP,1-hydroxypyrene) 和血液mtDNAcn.
- 统计分析评估了暴露标志物和mtDNAcn之间的关联,控制年龄,性别,季节和吸烟.
主要成果:
- 随着年龄的增长,mtDNAcn显著下降.
- 在总环境PAH或1-基和mtDNAcn.cn之间没有发现显著的关联.
- 尿液中的1-尼托烯代谢物 (6-OHNP和1-NAAP) 的度与mtDNAcn.cn的增加显著相关.
结论:
- 吸收的1-尼托烯的新陈代谢产生活性氧物种 (ROS),导致线粒体DNA受损.
- 增加mtDNAcn是一个线粒体功能障碍的标志物,是由于暴露于酸的结果.
- 这凸显了空气中PAH中酸所带来的特定风险.
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