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通过围产期干预预防疾病易感性的跨代传播
Takahiro Nemoto1, Norimasa Sagawa2
1Department of Bioregulatory Science (Physiology), Nippon Medical School, Tokyo 113-8602, Japan.
Endocrine journal
|November 21, 2023
概括
低出生体重与胎儿营养不良有关,增加非传染性疾病 (NCD) 的风险. 早期的环境因素及其跨代遗传影响终身健康和疾病倾向.
科学领域:
- 发育生物学是发展生物学.
- 流行病学 流行病学
- 遗传学 是一个遗传学.
背景情况:
- 健康和疾病的发育起源 (DOHaD) 理论认为,早期的生活环境暴露,特别是在胎儿发育期间,显著影响长期健康结果和非传染性疾病 (NCD) 风险.
- 巴克的假设最初将低出生体重 (LBW) 与晚年非传染性疾病联系在一起,形成了DOHaD理论的基础.
结论:
- 早期发育的可塑性会产生持久的生理变化,使人易患NCD.
- 了解疾病风险的跨代遗传对于预防策略至关重要.
- 胎儿营养不良模型提供了关于NCD发展中的遗传和环境相互作用的见解.
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