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掠夺性火虫及其有毒的火虫猎物已经发展出不同的毒素抵抗策略

Lu Yang¹, Flora Borne², Anja Betz³

¹Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA.

Current biology : CB

|November 21, 2023

概括

火虫通过改变Na+,K+-ATPase (NKA) 进化对有毒心肌类固醇 (CTS) 的耐药性. 照片火虫开发了多个耐药的NKA基因拷贝,与他们的猎物和亲属不同,使得捕食行为成为可能.

科学领域:

进化生物学进化生物学
生物化学生物化学
生态生态学生态生态学

背景情况:

毒性心性类固醇 (CTS) 是火虫 (Lampyridae) 中的防御化合物,可以抑制Na+,K+-ATPase (NKA).
光属通过捕食其他火虫来独特地获得CTS,需要独特的自我中毒避免策略.
在Photuris和其他虫之间对比CTS生理学表明NKA抵抗的演化路径不同.

研究的目的:

为了研究光虫中NKA对CTS的抗性的进化机制.
了解基因重复和新功能化如何导致Photuris掠夺性的生活方式.
为了比较NKA在Photuris中的进化与他们的火虫猎物和其他火虫血统的进化.

主要方法:

在火物种中对ATPα基因 (NKA标) 的比较进化分析.
在Drosophila中进行基因编辑,以研究ATPα对象的功能影响.
在Photuris.中分析基因复制事件和差异性基因表达.

主要成果:

光和它们的猎物都具有CTS耐药的NKAs,最初的抵抗步骤在火虫血统中共享.
光氏系经历了ATPα的多重基因重复,导致具有增强CTS抗性的对应物.
其他火虫物种保持单一的ATPα副本,这表明Photuris的独特进化轨迹.

结论:

基因重复和ATPα的新功能化是Photuris中CTS耐药性的关键驱动因素.
这些遗传适应促进了Photuris掠食性的进化,使他们可以食用有毒的火虫.
这项研究强调了基因重复在使野生动物能够发挥新的生态作用和适应的作用.

关键词:

补偿性演变是一种补偿性演变.补偿性的替代品补偿性的替代品目标站点的不敏感性

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