平行神经通路控制摄入量和味道价值
Yameng Zhang1, Allan-Hermann Pool2, Tongtong Wang1
1Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Cell
|November 21, 2023
概括
根据含量, 大脑会改变盐的偏好. 在后脑和前脑的不同神经回路控制盐
科学领域:
- 神经科学
- 味道感知
- 恒温状态
背景情况:
- 盐的享乐价值随着内部状态的变化而变化,
- 这种依赖于状态的盐价值开关背后的神经机制尚不清楚.
研究的目的:
- 为了阐明控制盐的取决于状态的神经回路.
- 识别涉及盐味感知和耐受性的特定细胞类型和分子通路.
主要方法:
- 转录组学用于状态到细胞类型的映射.
- 在哺乳动物模型中进行神经操纵.
- 电子生理记录以评估味道敏感性
主要成果:
- 在后脑和前脑的不同神经回路 (lamina terminalis, LT) 控制盐的价值.
- 一个表达前列腺素E2受体 (Ptger3) 的特定类型的LT神经元编码盐耐受性.
- 这些LT神经元通过前列腺素E2-Ptger3轴调节厌味敏感性.
结论:
- 盐的偏好是通过不同的食欲 (后脑) 和耐受性 (前脑) 信号双向调节的.
- 这种双态调节根据身体的内部状态来决定的摄入量.
- 确定了前列腺素E2-Ptger3途径在调节盐味厌恶中的新角色.
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