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瘤芽是头部和部状细胞癌的预后因素:一个全面的元分析和试验序列分析

Fábio França Vieira E Silva¹, Vito Carlo Alberto Caponio², Mario Pérez-Sayáns¹

¹Oral Medicine, Oral Surgery and Implantology Unit (MedOralRes), Faculty of Medicine and Dentistry, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain; ORALRES Group, Health Research Institute of Santiago de Compostela (FIDIS), 15782 Santiago de Compostela, Spain.

Critical reviews in oncology/hematology

|November 21, 2023

概括

瘤芽 (结核病) 与头部和部状细胞癌 (HNSCC) 的较差生存结果显著相关. 高结核病率表明预后更差,包括总体,无病和疾病特异性存活率降低.

科学领域:

在瘤学瘤学.
病理学病理学病理学
癌症研究癌症研究

背景情况:

瘤芽 (TB) 是一种与各种癌症死亡率相关的组织病理特征.
它的预后意义因瘤部位而异,需要在头部和部状细胞癌 (HNSCC) 中进行具体的调查.

研究的目的:

进行一项元分析,调查瘤芽 (TB) 与HNSCC患者结局之间的关联.
量化结核病对HNSCC生存指标的预后影响.
评估结核病与HNSCC中的淋巴结转移之间的关系.

主要方法:

一项对42项相关研究的综合元分析.
统计分析整体生存率 (OS),无病生存率 (DFS) 和疾病特异性生存率 (DSS) 的危险比率 (HR).
评估结核病和淋巴结转移 (LNM) 之间的关联,使用几率比率 (OR).
试验序列分析 (TSA) 用于最终结果验证.

主要成果:

高结核病与明显更糟糕的生存状况 (HR 2.63),DFS (HR 1.88) 和DSS (HR 2.14) 有关.
在结核病和淋巴结转移 (LNM) (OR 4.48) 之间发现了强烈的关联.
试验序列分析证实了疾病特异性生存率的最终结果.

结论:

这一元分析提供了令人信服的证据,表明瘤芽与HNSCC的更差预后之间存在显著的关联.
结核病是HNSCC患者的关键预后生物标志物,影响生存和转移.

关键词:

头部和部状细胞癌瘤进行元分析分析.预测预后预测预测瘤的芽正在发生.

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