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Updated: Jul 10, 2025

Pooled shRNA Screen for Reactivation of MeCP2 on the Inactive X Chromosome
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Pooled shRNA Screen for Reactivation of MeCP2 on the Inactive X Chromosome

Published on: March 2, 2018

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转子子波在X染色体剂量补偿的快速演变中重塑了表观基因组景观

David C H Metzger1, Imogen Porter2, Brendan Mobley3

  • 1Department of Zoology and Biodiversity Research Centre, University of British Columbia, Vancouver, British Columbia, V6T 1Z4, Canada; dmetzger@zoology.ubc.ca.

Genome research
|November 21, 2023
PubMed
概括

新进化的X染色体剂量补偿在鱼 *Poecilia picta *是由重复的元素扩张驱动的. 这种扩展引入了YY1转录因子动图,改变了表观基因组,并使全染色体基因调节成为可能.

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In animals, gender is determined by the number and type of sex chromosome. For example, human females have two X chromosomes, and males have one X and one Y chromosome, whereas C.elegans with one X chromosome is a male, and the one with two X chromosomes is a hermaphrodite.
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