血管负担缓和了老年人ADHD和认知之间的关系
Brandy L Callahan1, Sara Becker1, Joel Ramirez2
1Department of Psychology (BLC, SB), University of Calgary, Calgary, Alberta, Canada; Hotchkiss Brain Institute (BLC, SB), Calgary, Alberta, Canada.
概括
老年人的注意力缺陷/多动性障碍 (ADHD) 在存在白质超强度 (WMH) 时加剧认知衰退. 低WMH水平减轻了这种效应,但高水平增加了ADHD患者的认知风险.
科学领域:
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
- 精神病学是一个精神病学.
背景情况:
- 注意缺陷/多动障碍 (ADHD) 越来越被认为是老年人认知障碍的潜在危险因素.
- 脑血管负担,特别是白质超强度 (WMH),是老年大脑中常见的发现,与认知能力下降有关.
研究的目的:
- 研究大脑血管负担 (WMH) 作为ADHD和晚年认知障碍之间的关系的调解者.
- 为了检查WMH卷是否影响老年人ADHD和认知表现之间的关联.
主要方法:
- 涉及ADHD和没有ADHD的老年人的横截面观察研究.
- 使用半自动核磁共振管道量化周周结膜 (pWMH) 和深白质超强度 (dWMH).
- 评估认知功能,包括记忆,处理速度和执行功能,以调整性别的调解模型.
主要成果:
- 通过WMH负担对ADHD对认知的中介影响没有得到支持.
- 观察到WMH具有显著的缓解作用:在高和中等WMH水平时,ADHD与认知表现 (记忆,速度,执行功能) 有负面关联,但在低水平时没有.
结论:
- ADHD增加了老年人对WMH负面认知影响的易感性.
- 患有多动症的老年人可能面临更高的认知障碍风险,如果他们表现出大量的深层WMH (>61 mm3) 和周周结膜WMH (>260 mm3).
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