相关实验视频

Updated: Jul 10, 2025

SNARE-mediated Fusion of Single Proteoliposomes with Tethered Supported Bilayers in a Microfluidic Flow Cell Monitored by Polarized TIRF Microscopy
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SNARE-mediated Fusion of Single Proteoliposomes with Tethered Supported Bilayers in a Microfluidic Flow Cell Monitored by Polarized TIRF Microscopy

Published on: August 24, 2016

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卡-SNARE合成素18调解了脂质滴滴与SNAP23和SEC22B的融合

Yuhui Fu1, Binbin Ding2, Xiaoxia Liu3

  • 1Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Department of Pathophysiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Cell discovery
|November 21, 2023
PubMed
概括

研究人员发现了一种新的SNARE蛋白质复合体,syntaxin 18 (STX18)-SNAP23-SEC22B,它驱动脂滴 (LD) 融合. 这一发现揭示了控制LD大小和数量的关键机制在代谢调节中.

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SNAREs and Membrane Fusion

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The translocon complex situated on the ER membrane is the main gateway for the protein secretory pathway. It facilitates the transport of nascent peptides into the ER lumen and their insertion into the ER membrane.
Sec61 protein conducting channel
In eukaryotes, the translocon complex comprises a core heterotrimeric translocator channel called the Sec61 complex. This channel includes three transmembrane proteins, Sec61α, Sec61β, and Sec61γ, and is the largest subunit of the...
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Cotranslational Protein Translocation

Translocation of proteins across membranes is an ancient process that occurs even in bacteria and archaebacteria. In fact, the components of the translocation machinery are still conserved between prokaryotes and eukaryotes.
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