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具有高空间分辨率的小脑核可视化,临床上可用的全身PET扫描仪
Yuki Shinohara1, Masanobu Ibaraki2, Keisuke Matsubara2,3
1Department of Radiology and Nuclear Medicine, Research Institute for Brain and Blood Vessels-Akita, 6-10 Senshu-kubota-machi, Akita, 010-0874, Japan. shino-y@akita-noken.jp.
Annals of nuclear medicine
|November 21, 2023
概括
全身光倍增器PET扫描仪可以在小脑干核中可视化生理18F-氧糖 (18F-FDG) 的吸收. 使用64次代与飞行时间和点传播函数重建提供了最清晰的可视化.
科学领域:
- 核医学就是核医学.
- 放射学 放射学是一门学科.
- 神经成像是一种神经成像.
背景情况:
- 小脑干核中18F-氧葡萄糖 (18F-FDG) 的生理吸收很难用标准的PET扫描仪可视化.
- 全身 (WB) 光倍增器正子发射断层扫描 (SiPM-PET) 扫描仪提供了更好的灵敏度和分辨率.
研究的目的:
- 用WB SiPM-PET扫描仪评估大脑干核中18F-FDG吸收的可见性.
- 为了确定顺序子集期望最大化 (OSEM) 重建的最佳代数,使用飞行时间 (TOF) 和点传播函数 (PSF) 进行增强的可视化.
主要方法:
- 十个健康的受试者接受了18F-FDG PET/CT和脑MRI.
- 使用OSEM重建PET图像,使用4,16,64和256次代,结合TOF和PSF.
- 分析了MR-coregistered PET图像,以确定各种脑干核中的18F-FDG吸收可见性.
主要成果:
- 代64证明了18F-FDG吸收在大多数脑干细胞核中的最佳可视化,包括下层橄叶细胞核,中脑核和侧侧/中侧生殖细胞核.
- 代64清晰可视化了100个评估结构中的98个结构中的FDG积累.
- 其他代显示出不同程度的可见性,代16是牙核和红色/亚体核的最佳.
结论:
- 临床上可用的WB SiPM-PET扫描仪对于可视化小脑核中的生理18F-FDG吸收是有效的.
- 用TOF和PSF进行OSEM重建的足够高的代数 (例如64),对于最佳的图像质量和诊断实用性至关重要.
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