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一个常见的途径,用于Aβ42的洗剂辅助寡合化

Fidha Nazreen Kunnath Muhammedkutty1, Ramesh Prasad1, Yuan Gao2

  • 1Department of Chemistry, University of Illinois Chicago, Chicago, IL, 60607, USA.

Communications biology
|November 21, 2023
PubMed
概括

二硫酸盐 (SDS) 和DPC菌根稳定了粉样β (Aβ) 寡合体,揭示了一个共同的途径. 在Aβ42中的特定甘氨酸残留物为洗剂尾部创建稳定孔,影响细胞界面的聚合.

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