白细胞瘤对早产儿视网膜病变的影响
Zhihong Sun1, Lu He1, Congcong Zhao1
1Department of Neonatology, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, 33 Longhuwaihuan Road, Zhengzhou, 450018, Henan, China.
Scientific reports
|November 21, 2023
概括
产后白细胞症是炎症的征兆,与早产婴儿的严重视网膜病变 (ROP) 有关. 使用白细胞计数的早期检测可能会改善高风险新生儿的结果.
科学领域:
- 新生儿医学 新生儿医学
- 眼科医生 眼科 眼科
- 儿科重症监护 儿科重症监护
背景情况:
- 产后白细胞症表明炎症,并与各种婴儿健康问题有关.
- 炎症过程是早产视网膜病变 (ROP) 和其他视力障碍的已知风险因素.
研究的目的:
- 调查产后白细胞症与早产婴儿ROP发生率和严重程度之间的关联.
- 为了确定白细胞 (WBC) 计数是否可以预测极度早产新生儿的严重ROP.
主要方法:
- 一项队列研究包括2015年9月至2021年3月期间入院的早产婴儿 (妊娠28周以下).
- 婴儿被分为白细胞瘤组 (WBC ≥30 × 10 ^ 9 / L) 和匹配的对照组.
- 对比了ROP的发生率和预后;ROC曲线分析了WBC计数与严重ROP的相关性.
主要成果:
- 血清细胞瘤组表现出更高的内出血,白血病,败血症和支气管肺功能失调的发病率.
- 在患有白细胞病的婴儿中,严重的ROP发生率和需要拉尼比祖马布注射的需要显着更高.
- 19.1 × 10^9/L的白细胞计数截止值显示了检测严重ROP的高灵敏度 (88.6%) 和特异性 (77.3%).
结论:
- 产后白细胞症与早产婴儿严重ROP的风险增加有关.
- 升高的白细胞计数可能作为严重ROP的预测标记在这个脆弱的人群.
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