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通过在单片药片上重复压缩来进行粘贴检测

James Thomas^1,2, Phuong Bui², Antonios Zavaliangos³

¹Drug Substance Development - Material Science, GlaxoSmithKline, 1250 S, Collegeville Rd, Collegeville, PA, 19426, United States of America.

AAPS PharmSciTech

|November 22, 2023

概括

早期检测药片粘附是制药制造业的关键. 一种新的单片多压缩 (STMC) 方法使用激光传感器以最小的材料评估粘合倾向,帮助早期的研发.

科学领域:

制药制造业制药制造业制药制造业
材料科学材料科学材料科学
工艺工程是过程工程.

背景情况:

药片粘附,材料粘附于冲击,损害了药片的质量,并停止了生产.
早期发现粘结风险在研发中至关重要,以减轻延迟和成本.
在早期药物开发中,有限的材料可用性给传统的粘贴评估带来了挑战.

研究的目的:

引入和验证一种节约材料的方法来评估药片粘附的倾向性.
评估单片多压缩 (STMC) 与激光传感相结合的疗效,用于早期的研发.

主要方法:

使用单片药片多重压缩 (STMC) 来重复压缩单片药片.
采用高度灵敏的激光反射传感器来检测穿孔上的物质积累.
经过测试的布洛芬粉末混合物,以评估不同配方和冲击速度的粘合倾向.

主要成果:

在各种粉末配方中,STMC成功地区分了粘合倾向.
该方法复制了在不同的冲击速度下观察到的粘合趋势.
激光传感器提供了对粘附材料的敏感检测.

结论:

STMC是一种高度节约材料的方法,适用于早期的药物开发.
这种技术可以早期评估药片粘附倾向,促进及时的缓解策略.
结合STMC和激光传感,为预测和管理平板电脑粘合提供了强大的解决方案.

关键词:

在STMC中,它是STMC.粘附性粘附性粘附性粘附性激光传感器是一个激光传感器.粘着的粘着的粘着药片药片药片药片药片药片

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