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相关概念视频

Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

134
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
134

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相关实验视频

Updated: Jul 10, 2025

Coherent anti-Stokes Raman Scattering CARS Microscopy Visualizes Pharmaceutical Tablets During Dissolution
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通过在单片药片上重复压缩来进行粘贴检测.

James Thomas1,2, Phuong Bui2, Antonios Zavaliangos3

  • 1Drug Substance Development - Material Science, GlaxoSmithKline, 1250 S, Collegeville Rd, Collegeville, PA, 19426, United States of America.

AAPS PharmSciTech
|November 22, 2023
PubMed
概括

早期检测药片粘附是制药制造业的关键. 一种新的单片多压缩 (STMC) 方法使用激光传感器以最小的材料评估粘合倾向,帮助早期的研发.

关键词:
在STMC中,它是STMC.粘附性 粘附性 粘附性 粘附性激光传感器是一个激光传感器.粘着的粘着的粘着药片 药片 药片 药片 药片 药片

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相关实验视频

Last Updated: Jul 10, 2025

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科学领域:

  • 制药制造业 制药制造业 制药制造业
  • 材料科学 材料科学 材料科学
  • 工艺工程是过程工程.

背景情况:

  • 药片粘附,材料粘附于冲击,损害了药片的质量,并停止了生产.
  • 早期发现粘结风险在研发中至关重要,以减轻延迟和成本.
  • 在早期药物开发中,有限的材料可用性给传统的粘贴评估带来了挑战.

研究的目的:

  • 引入和验证一种节约材料的方法来评估药片粘附的倾向性.
  • 评估单片多压缩 (STMC) 与激光传感相结合的疗效,用于早期的研发.

主要方法:

  • 使用单片药片多重压缩 (STMC) 来重复压缩单片药片.
  • 采用高度灵敏的激光反射传感器来检测穿孔上的物质积累.
  • 经过测试的布洛芬粉末混合物,以评估不同配方和冲击速度的粘合倾向.

主要成果:

  • 在各种粉末配方中,STMC成功地区分了粘合倾向.
  • 该方法复制了在不同的冲击速度下观察到的粘合趋势.
  • 激光传感器提供了对粘附材料的敏感检测.

结论:

  • STMC是一种高度节约材料的方法,适用于早期的药物开发.
  • 这种技术可以早期评估药片粘附倾向,促进及时的缓解策略.
  • 结合STMC和激光传感,为预测和管理平板电脑粘合提供了强大的解决方案.