估计传染性和非传染性精神和神经发育多基因评分对青少年情绪问题的影响
Amy Shakeshaft1,2, Joanna Martin3,4, Charlotte A Dennison3,4
1Wolfson Centre for Young People's Mental Health, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK. shakeshafta@cardiff.ac.uk.
Molecular psychiatry
|November 22, 2023
概括
父母对焦虑,抑郁,多动症和自闭症的遗传责任有助于青年情绪问题,特别是在青春期. 非传染性遗传效应显示出有限的支持,这表明环境因素在家族风险中起着更大的作用.
科学领域:
- 遗传学 是一个遗传学.
- 精神病学是一个精神病学.
- 发展心理学 发展心理学
背景情况:
- 焦虑和抑郁是家族性和遗传性的,早期发病表明遗传影响.
- 跨代研究表明,环境风险可能主要解释年轻人的情绪问题传播.
- 父母的遗传责任是一个潜在的,但研究不足的因素,影响后代的情感福祉.
研究的目的:
- 调查父母非传染性遗传责任对青少年情绪问题的贡献.
- 区分传染性与非传染性多基因评分对青少年情绪障碍的影响.
- 分析这些跨不同祖先和发展阶段的关联.
主要方法:
- 利用英国千年队列研究与欧洲和南亚样本,包括父母基因组数据.
- 计算的传递 (PGST) 和非传递 (PGSNT) 多基因得分,用于焦虑,抑郁,双相情感障碍,多动症,自闭症和精神分裂症.
- 评估了3至17岁的青少年的情绪障碍和症状得分,使用"优势和困难问卷".
主要成果:
- 焦虑和抑郁的传递多基因分数 (PGST) 与6岁以后的青少年情绪问题有关,在青春期达到顶峰.
- 对于ADHD和ASD的PGST也显示了与青春期 (年龄11-17岁) 情绪问题的关联.
- 影响青年情绪问题的非传染性多基因分数 (PGSNT) 的证据较弱,特别是在欧洲样本中.
结论:
- 抑郁症,焦虑症,多动症和自闭症的遗传遗传责任显著导致青少年的情绪问题,其影响在青春期加剧.
- 研究结果不支持这样的假设,即父母非传染性多基因责任会通过培养效应影响后代的情绪问题.
- 这项研究强调了直接遗传传染对通过父母环境间接遗传影响在青少年情绪健康中的作用.
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