下和前立腺过敏免疫疗法药片的耐受性:一个随机试点研究
Marie-Lee Simard1, Natalija Novak2, Jean-Philippe Drolet1
1Clinique Spécialisée en Allergie de la Capitale, Québec, Québec, Canada.
概括
对过敏性鼻炎/结膜炎的过敏免疫疗法 (AIT) 药片的静脉管注射导致更严重的副作用和更高的中止率,与标准的语言下路线相比. 语言下AIT仍然是推的护理标准.
科学领域:
- 免疫学 免疫学 免疫学
- 过敏学 过敏学
- 药理学 药理学是指药理学的学科.
背景情况:
- 局部应用部位反应是针对过敏性鼻炎/结膜炎 (AR/C) 的亚舌性过敏免疫疗法 (AIT) 药片常见的.
- 静脉AIT-平板药物被探索为减少不良事件 (AE) 的潜在替代方案,由于较低的巨细胞密度.
- 这项试点研究比较了在AR/C.的成年人体内,前体和舌下AIT片的耐受性.
研究的目的:
- 为了评估前体内AIT药片的耐受性,与舌下药剂相比.
- 在AIT的初始阶段评估与治疗相关的局部不良事件 (TRAE) 的发生率和严重程度.
主要方法:
- 164名AR/C的成年受试者被随机分为28天的前庭或舌下AIT平板药物.
- 主要终点是前28天当地TRAE的严重程度.
- 试验对象每天接受树花粉,草花粉,拉格韦花粉或家用灰尘虫AIT片.
主要成果:
- 前置组报告了数字上更高的严重TRAE (12.3%对6.0%) 的受试者百分比.
- 在前体组中,显著更多的受试者经历了至少一个TRAE (95.1%与81.9%,p=0.01).
- 由于AE导致的停药率在前体组中更高 (12.3%对3.6%).
结论:
- 与语言下服药相比,静脉内服药AIT片显示严重TRAE,整体TRAE和停药率在数值上更高.
- 在治疗AR/C时,口下注射应该仍然是AIT片的护理标准.
- 可能需要进一步的研究来探索AIT的替代药物管理途径.
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