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高强度间歇训练减轻了骨肌肉中耗尽的运动诱导的HSP70辅助选择性自
Jiao Lu1,2, Liu-Mei Zhang1, Jing-Jing Liu1
1School of Sports and Health, Nanjing Sport Institute, Nanjing, 210014, China.
The journal of physiological sciences : JPS
|November 22, 2023
概括
耗尽的运动会激活伴侣辅助选择性自 (CASA),以维持肌肉蛋白质稳定. 运动前高强度间歇训练 (HIIT) 通过减轻蛋白质聚合,减少肌肉损伤和CASA激活.
科学领域:
- 运动生理学 运动生理学
- 细胞生物学 细胞生物学
- 分子生物学分子生物学
背景情况:
- 蛋白质稳定对于肌肉功能至关重要,尤其是在劳累性活动期间.
- 伴奏辅助选择性自 (CASA) 在清除受损蛋白质方面发挥作用.
- 高强度间歇训练 (HIIT) 诱导肌肉适应,可能会影响运动反应.
研究的目的:
- 为了研究CASA在维持全面炼期间蛋白质静止的作用.
- 检查HIIT前肌肉适应如何影响CASA对耗尽性运动的反应.
主要方法:
- 鼠被分配到控制,彻底炼或HIIT + 彻底炼组.
- 评估了肌纤维细胞损伤,BiP,HSP70,BAG3,乌比奎丁和自标志物.
- 分析了HSP70/BAG3复合体内的相互作用.
主要成果:
- 消耗性运动增加了肌纤维细胞损伤,BiP,HSP70,BAG3,全方位素和CASA活动.
- 在HIIT前的干预减轻了肌纤维细胞损伤和BiP水平.
- HIIT预调导致HSP70/BAG3复合体形成减少,选择性自减少.
结论:
- 耗尽的运动可以增强CASA,通过清除蛋白质聚合物来保持肌肉蛋白质稳定.
- 前HIIT适应减轻了运动诱导的肌肉损伤和展开的蛋白质反应,可能通过抑制CASA增强.
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