辅助增强力运动激活可减少耐火不安腿综合征的阿片类药物:一个前性的,开放的,单臂临床试验
Mark J Buchfuhrer1,2, Asim Roy3, Stephanye Rodriguez2,4
1Stanford University School of Medicine, Stanford, CA, USA.
BMC neurology
|November 22, 2023
概括
性运动激活 (TOMAC) 疗法帮助70%的不安腿综合征 (RLS) 患者减少至少20%的阿片类药物剂量,而不会使症状恶化. 这种非药理学方法提供了一种潜在的方法来降低与长期使用阿片类药物对RLS相关的风险.
科学领域:
- 神经学 神经学
- 医疗器械 医疗器械
- 疼痛管理 疼痛管理
背景情况:
- 不安腿综合征 (RLS) 影响了许多耐标准治疗的患者.
- 强烈推用于耐火性RLS的阿片类药物,但具有重大风险和副作用.
- 减少阿片类药物剂量对于改善患者安全和治疗结果至关重要.
研究的目的:
- 调查Tonic Motor Activation (TOMAC) 的有效性,使RLS患者能够降低阿片类药物剂量.
- 评估TOMAC治疗是否可以保持RLS症状控制,同时降低阿片类药物依赖.
主要方法:
- 一个前性的,开放的,单臂临床试验,涉及20名耐火性RLS的成年人,服用稳定的阿片类药物剂量 (≤60MME/天).
- 在RSS症状爆发期间,参与者使用TOMAC设备在神经上进行30分钟的会话.
- 片剂量每2-3周次降低,治疗成功的定义是临床医师全球改善印象 (CGI-I) 评分超过5.
主要成果:
- 70%的参与者 (共20人中14人) 成功降低了他们的阿片类药物剂量≥20%,同时达到CGI-I得分≤5.5.
- 平均阿片类药物剂量减少为29.9%,从39.0降至26.8MME/天.
- 降低阿片类药物剂量的平均CGI-I得分为4.0,表明RLS严重程度没有显著变化.
结论:
- 在耐火性RLS患者中,TOMAC治疗有助于显著降低阿片类药物剂量.
- 这种非药物干预似乎有效地管理RLS症状,同时降低阿片类药物暴露.
- 托马克提出了一个有希望的策略,以减轻与耐火性RLS的长期阿片类药物治疗相关的风险.
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