与过度诊断良性肺结节与恶性瘤相关的因素:回顾性队列研究
Xirui Duan1, Zhiqiang Ouyang1, Shasha Bao1
1Department of Radiology, Yan'an Hospital of Kunming City (Yan'an Hospital Affiliated to Kunming Medical University; Yunnan Cardiovascular Hospital), Kunming, China.
BMC pulmonary medicine
|November 22, 2023
概括
一个新的手术前模型有助于区分良性和恶性肺结节 (PNs). 它还确定了导致过度诊断的因素,旨在减少PNS的不必要手术.
科学领域:
- 肺部病理学 肺部病理学
- 放射学 放射学是一门学科.
- 在瘤学瘤学.
背景情况:
- 肺结节 (PNs) 需要准确的诊断来区分良性和恶性类型.
- 将良性PNS过度诊断为恶性,可能导致不必要的外科手术.
研究的目的:
- 开发一个手术前模型来区分良性和恶性肺结节 (PNs).
- 在成像上识别与良性PNS过度诊断相关的因素.
主要方法:
- 对357名407名PN患者进行了回顾性研究,这些患者正在接受手术组织病理学评估.
- 使用CT扫描功能和后勤回归分析开发手术前模型.
- 计算过度诊断率和识别相关风险因素.
主要成果:
- 术前模型准确地识别了良性PNS,在验证组中AUC为0.88.
- 鉴定良性PN的关键特征包括缺少螺纹和血管融合,以及较大的病变大小.
- 良性PNS的过度诊断率为50%,非固体结节,膜收缩,血管收和更大的尺寸是危险因素.
结论:
- 一个经过验证的术前模型可以帮助对良性和恶性肺结节 (PNs) 的差异诊断.
- 了解过度诊断因素可以帮助临床医生和放射科医生尽量减少PNS的不必要手术.
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