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瘤衍生的外体 linc00881诱导肺纤维细胞激活,并促进骨髓瘤的肺迁移

Xinyu Chang^1,2, Qiuyu Tan³, Jinwen Xu³

¹Department of Oncology, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu, 241002, Anhui, China.

Cancer cell international

|November 22, 2023

概括

骨髓瘤外基因组含有一种新型的长非编码RNA,linc00881,通过转化肺纤维细胞驱动肺转移. 这一发现为骨髓瘤肺部迁移提供了一个新的治疗点.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
细胞生物学细胞生物学

背景情况:

骨髓瘤 (OS) 经常转移到肺部,但分子驱动因素尚未完全理解.
外体体与瘤细胞迁移有关,包括骨髓瘤肺转移.
在这个过程中,外体衍生长非编码RNAs (lncRNAs) 的特定作用在很大程度上是未知的.

研究的目的:

为了研究外体源 lncRNAs 在骨髓瘤肺转移中的作用.
确定和描述一种参与骨髓瘤细胞迁移和肺微环境调节的新型lncRNA.
阐明这种lncRNA促进肺转移的分子机制.

主要方法:

在骨髓瘤衍生的外体内发现新型lncRNA (linc00881) 的鉴定和特征.
试验室试验评估linc00881对骨髓瘤细胞迁移和肺纤维细胞激活的影响.
涉及RNA-RNA相互作用 (海绵),蛋白质表达分析 (MMP2) 和信号通路激活 (NF-κB) 的机制研究.

主要成果:

在骨髓癌细胞中发现了一种新型的外体内 lncRNA,linc00881.
linc00881促进骨肉瘤细胞向肺部迁移,并诱导肺纤维细胞转化为癌症相关纤维细胞 (CAF).
外体linc00881通过海绵化miR-29c-3p调节肺纤维细胞中MMP2的表达,激活NF-κB通路,并导致促炎性细胞因子 (IL-1β,IL-6,IL-8) 的分泌.

结论:

骨髓瘤衍生的外体细胞通过linc00881.1.通过肺纤维细胞进行细胞间通信.
该linc00881/miR-29c-3p/MMP2轴通过调节肺微环境来促进骨肉瘤肺转移.
这一途径代表了抑制骨髓瘤肺转移的潜在治疗标.

关键词:

肺纤维细胞激活的过程肺部迁移肺部迁移肺部迁移这就是MMP2的MMP2.骨质肉瘤骨质肉瘤是什么 linc00881 一个很好的方法.

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